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- W1974521175 abstract "Cyclin-dependent kinase 5 (Cdk5) has been implicated in the migration, maturation and survival of neurons born during embryonic development. New evidence suggests that Cdk5 has comparable but also distinct functions in adult neurogenesis. Here we summarize accumulating evidence on the role of Cdk5 in regulation of the cell cycle, migration, survival, maturation and neuronal integration. We specifically highlight the many similarities and few tantalizing differences in the roles of Cdk5 in the embryonic and adult brain. We discuss the signaling pathways that might contribute to Cdk5 action in regulating embryonic and adult neurogenesis, highlighting future research directions that will help to clarify the mechanisms underlying lifelong neurogenesis in the mammalian brain." @default.
- W1974521175 created "2016-06-24" @default.
- W1974521175 creator A5060118711 @default.
- W1974521175 creator A5061477553 @default.
- W1974521175 creator A5072968010 @default.
- W1974521175 creator A5089019914 @default.
- W1974521175 date "2009-11-01" @default.
- W1974521175 modified "2023-10-17" @default.
- W1974521175 title "Making a neuron: Cdk5 in embryonic and adult neurogenesis" @default.
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- W1974521175 doi "https://doi.org/10.1016/j.tins.2009.07.002" @default.
- W1974521175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2767479" @default.
- W1974521175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19782409" @default.
- W1974521175 hasPublicationYear "2009" @default.
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