FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974525908> ?p ?o ?g. }

• W1974525908 endingPage "1791" @default.
• W1974525908 startingPage "1781" @default.
• W1974525908 abstract "Levels of cyclooxygenase (COX)-2 and its metabolite prostaglandin E2 (PGE2) are frequently increased in colon cancer and other cancers including lung cancer. Non-steroidal anti-inflammatory drugs are considered to have chemo-preventive effects on these diseases by reducing the biosynthesis of PGE2 via their inhibition of COX-2. Although the COX-2/PGE2 pathway may directly impact on lung carcinogenesis, some population-based cohort studies of NSAIDs showed no significant protective effects. In this study, using human non-small-cell lung cancer A549 cells, we examined the effects of indomethacin, a potent NSAID, on the growth and motility of lung cancer cells. Besides inhibiting PGE2 production and cellular growth, indomethacin caused drastic morphological changes with a loss of stress fibers in a time- and dose-dependent manner. Interestingly, the change in cellular shape caused by indomethacin was not seen when the cells were treated with aspirin or diclofenac, two other NSAIDs, despite the concentrations used being sufficient to inhibit PGE2 production. The indomethacin-induced morphological changes in A549 cells were accompanied by a reduction in levels of the adhesion molecule E-cadherin and a component of basal lamina, collagen IV, as well as an increase in the activity of a collagenase, matrix metalloprotease-9. Furthermore, indomethacin-induced shape changes resulted in enhanced motility via regulation of peroxisome proliferator-activated receptor γ. The dual effects of indomethacin, inhibition of cellular growth and enhancement of migration, would explain, to some extent, the difficulty in using this NSAID for lung cancer therapy." @default.
• W1974525908 created "2016-06-24" @default.
• W1974525908 creator A5013779606 @default.
• W1974525908 creator A5053909003 @default.
• W1974525908 creator A5066686743 @default.
• W1974525908 creator A5068275259 @default.
• W1974525908 creator A5089867564 @default.
• W1974525908 date "2011-12-01" @default.
• W1974525908 modified "2023-09-24" @default.
• W1974525908 title "Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: A novel cyclooxygenase-inhibition-independent effect" @default.
• W1974525908 cites W1633340712 @default.
• W1974525908 cites W1943317391 @default.
• W1974525908 cites W1964081206 @default.
• W1974525908 cites W1964352774 @default.
• W1974525908 cites W1967827309 @default.
• W1974525908 cites W1968531988 @default.
• W1974525908 cites W1979990833 @default.
• W1974525908 cites W1980689484 @default.
• W1974525908 cites W1984557698 @default.
• W1974525908 cites W1986357418 @default.
• W1974525908 cites W1989900054 @default.
• W1974525908 cites W2002354023 @default.
• W1974525908 cites W2004880100 @default.
• W1974525908 cites W2025647419 @default.
• W1974525908 cites W2026978308 @default.
• W1974525908 cites W2031659472 @default.
• W1974525908 cites W2033005746 @default.
• W1974525908 cites W2039060112 @default.
• W1974525908 cites W2042278676 @default.
• W1974525908 cites W2045707801 @default.
• W1974525908 cites W2046768665 @default.
• W1974525908 cites W2046884928 @default.
• W1974525908 cites W2047578735 @default.
• W1974525908 cites W2050693842 @default.
• W1974525908 cites W2053715810 @default.
• W1974525908 cites W2062778788 @default.
• W1974525908 cites W2073602994 @default.
• W1974525908 cites W2073652303 @default.
• W1974525908 cites W2078134150 @default.
• W1974525908 cites W2078424139 @default.
• W1974525908 cites W2080232352 @default.
• W1974525908 cites W2088404163 @default.
• W1974525908 cites W2096252197 @default.
• W1974525908 cites W2111963909 @default.
• W1974525908 cites W2115613198 @default.
• W1974525908 cites W2119623952 @default.
• W1974525908 cites W2119689902 @default.
• W1974525908 cites W2120859709 @default.
• W1974525908 cites W2130017811 @default.
• W1974525908 cites W2131088013 @default.
• W1974525908 cites W2136638726 @default.
• W1974525908 cites W2146654096 @default.
• W1974525908 cites W2146977839 @default.
• W1974525908 cites W2157201048 @default.
• W1974525908 cites W2157316963 @default.
• W1974525908 cites W2163545211 @default.
• W1974525908 cites W2190769602 @default.
• W1974525908 cites W3008770883 @default.
• W1974525908 doi "https://doi.org/10.1016/j.bcp.2011.07.096" @default.
• W1974525908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21840302" @default.
• W1974525908 hasPublicationYear "2011" @default.
• W1974525908 type Work @default.
• W1974525908 sameAs 1974525908 @default.
• W1974525908 citedByCount "23" @default.
• W1974525908 countsByYear W19745259082012 @default.
• W1974525908 countsByYear W19745259082013 @default.
• W1974525908 countsByYear W19745259082014 @default.
• W1974525908 countsByYear W19745259082017 @default.
• W1974525908 countsByYear W19745259082018 @default.
• W1974525908 countsByYear W19745259082019 @default.
• W1974525908 countsByYear W19745259082020 @default.
• W1974525908 countsByYear W19745259082022 @default.
• W1974525908 crossrefType "journal-article" @default.
• W1974525908 hasAuthorship W1974525908A5013779606 @default.
• W1974525908 hasAuthorship W1974525908A5053909003 @default.
• W1974525908 hasAuthorship W1974525908A5066686743 @default.
• W1974525908 hasAuthorship W1974525908A5068275259 @default.
• W1974525908 hasAuthorship W1974525908A5089867564 @default.
• W1974525908 hasConcept C121608353 @default.
• W1974525908 hasConcept C126322002 @default.
• W1974525908 hasConcept C181199279 @default.
• W1974525908 hasConcept C185592680 @default.
• W1974525908 hasConcept C2776256026 @default.
• W1974525908 hasConcept C2777956040 @default.
• W1974525908 hasConcept C2779013556 @default.
• W1974525908 hasConcept C2779689624 @default.
• W1974525908 hasConcept C2780664492 @default.
• W1974525908 hasConcept C2908647359 @default.
• W1974525908 hasConcept C502942594 @default.
• W1974525908 hasConcept C55493867 @default.
• W1974525908 hasConcept C71924100 @default.
• W1974525908 hasConcept C76419328 @default.
• W1974525908 hasConcept C81729549 @default.
• W1974525908 hasConcept C96232424 @default.
• W1974525908 hasConcept C98274493 @default.
• W1974525908 hasConcept C99454951 @default.
• W1974525908 hasConceptScore W1974525908C121608353 @default.
• W1974525908 hasConceptScore W1974525908C126322002 @default.

• next