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- W1974527354 abstract "CTRC-AACR San Antonio Breast Cancer Symposium: 2008 AbstractsAbstract #5131 Purpose: Initial phase I/II results utilizing balloon brachytherapy to deliver accelerated partial breast irradiation (APBI) in only 2-days in patients with early stage breast cancer are presented. Materials and Methods: From 3/2004 – 8/2007, 45 patients received adjuvant radiation therapy after lumpectomy with balloon brachytherapy in a phase I/II trial delivering 2800 cGy in 4 fractions of 700 cGy to a depth of 1 cm from the applicator surface. Inclusion criteria for the protocol included: (1) patient age > 40 years, (2) pathological confirmation of stage 0/I/II breast carcinoma, (3) > 3 cm tumor size, (4) 6 months. Results: The median age was 66 years (48-83) and median skin spacing was 12 mm (8-24). The median follow-up was 11.4 months (5.4-48 mo) with 20 patients (44%) followed greater than one year, 11 (24%) greater than 2 years and 6 (13%) greater than 3 years. At 6 months (n=43), grade II radiation dermatitis, induration, and hypopigmentation were 2% (n=1), grade III breast pain was reported in 2% (n=1). Infection was 16% (n=7) at 6 mo. Of these pts, only 4% (n=2) had a positive culture, whereas the others were treated empirically due to brisk erythema. Persistent seroma > 6 months was 30% (n=13). FN was seen in 9% (n=4), but only 1 pt required treatment. Rib fracture was seen in 5% (n=2). Cosmesis was good/excellent in 96% and fair in 4%. Conclusions: Treatment with balloon brachytherapy using a 2-day dose schedule resulted acceptable rates of grade II/III chronic toxicity rates and similar cosmetic results observed with standard 5-day APBI schedule.Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 5131." @default.
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- W1974527354 date "2009-01-15" @default.
- W1974527354 modified "2023-10-01" @default.
- W1974527354 title "Phase I/II study evaluating early tolerance in breast cancer patients undergoing accelerated partial breast irradiation treated with MammoSite balloon breast brachytherapy catheter using a two-day dose schedule." @default.
- W1974527354 doi "https://doi.org/10.1158/0008-5472.sabcs-5131" @default.
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