FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974536241> ?p ?o ?g. }

• W1974536241 endingPage "442" @default.
• W1974536241 startingPage "437" @default.
• W1974536241 abstract "1 A high density of [3H]-PK 11195 binding sites was present in gerbil cortical membranes (Bmax [3H]-PK 11195 1360 ± 71 fmol mg−1 protein) in comparison to rat cortical membranes (254 ± 21 fmol mg−1 protein). This effect was species-specific as similar findings were obtained with hippocampal membranes (Bmax 1430 ± 111 fmol mg−1 protein in gerbil, compared to 196 ± 31 in rat). 2 RO 5–4864, also a peripheral type benzodiazepine compound, displayed low affinity for the [3H]-PK 11195 site in the gerbil (pKi 6.57 ± 0.02 and 6.70 ± 0.12 in hippocampus and cortex respectively) compared to rat (pKi 8.16 ± 0.07 and 8.48 ± 0.02). Central benzodiazepine compounds, diazepam and flunitrazepam, also displayed this trend. 3 RO 5–4864 displaced [3H]-PK 11195 binding from gerbil and rat cortical membranes through a competitive interaction with Hill slopes close to unity. In both tissues, saturation isotherms of [3H]-PK 11195 binding indicated that the presence of RO 5–4864 caused changes in Kd without any effect on Bmax. In kinetic experiments, the presence of RO 5–4864 failed to modify the rate of dissociation of [3H]-PK 11195 from equilibrium in both rat and gerbil cortical membranes. 4 Forebrain ischaemia in the Mongolian gerbil (5 min bilateral carotid artery occlusion) with 7 days recovery caused a significant (P < 0.05) decrease in the density of hippocampal 5-HT1A binding sites labelled by [3H]-8-OH-DPAT (Bmax control, 393 ± 33 fmol mg−1 protein; ischaemic, 289 ± 21 fmol mg−1 protein) and an increase (P < 0.01) in [3H]-PK 11195 binding sites (Bmax control, 1430 ± 111 fmol mg−1 protein; ischaemic, 2160 ± 170 fmol mg−1 protein). Ischaemia and recovery had no effect on the affinity of either ligand. 5 Autoradiography experiments in gerbil brain sections revealed that the ischaemia-induced increase in [3H]-PK 11195 binding was consistent and significant in the CA1 subfield on the hippocampus (control, 152 ± 42 fmol mg−1 tissue; ischaemic; 314 ±; 43 fmol mg−1 tissue)." @default.
• W1974536241 created "2016-06-24" @default.
• W1974536241 creator A5006330314 @default.
• W1974536241 creator A5011577349 @default.
• W1974536241 creator A5080135978 @default.
• W1974536241 creator A5089868099 @default.
• W1974536241 date "1993-06-01" @default.
• W1974536241 modified "2023-09-24" @default.
• W1974536241 title "Changes in [3H]-PK 11195 and [3H]-8-OH-DPAT binding following forebrain ischaemia in the gerbil" @default.
• W1974536241 cites W1604272930 @default.
• W1974536241 cites W1911312547 @default.
• W1974536241 cites W1947273128 @default.
• W1974536241 cites W1965509912 @default.
• W1974536241 cites W1979159910 @default.
• W1974536241 cites W1982892406 @default.
• W1974536241 cites W1986643770 @default.
• W1974536241 cites W1994426001 @default.
• W1974536241 cites W2002002184 @default.
• W1974536241 cites W2002516266 @default.
• W1974536241 cites W2009384487 @default.
• W1974536241 cites W2009960829 @default.
• W1974536241 cites W2013725312 @default.
• W1974536241 cites W2016469055 @default.
• W1974536241 cites W2019900217 @default.
• W1974536241 cites W2020622209 @default.
• W1974536241 cites W2030930231 @default.
• W1974536241 cites W2035632600 @default.
• W1974536241 cites W2038909506 @default.
• W1974536241 cites W2042969415 @default.
• W1974536241 cites W2043813981 @default.
• W1974536241 cites W2045415882 @default.
• W1974536241 cites W2048034432 @default.
• W1974536241 cites W2051237723 @default.
• W1974536241 cites W2056472076 @default.
• W1974536241 cites W2068462317 @default.
• W1974536241 cites W2074631079 @default.
• W1974536241 cites W2076135710 @default.
• W1974536241 cites W2092459398 @default.
• W1974536241 cites W2093694387 @default.
• W1974536241 cites W2095306404 @default.
• W1974536241 cites W2099768623 @default.
• W1974536241 cites W2101073029 @default.
• W1974536241 cites W2120603676 @default.
• W1974536241 cites W2157669624 @default.
• W1974536241 cites W2159239201 @default.
• W1974536241 cites W2319511828 @default.
• W1974536241 cites W266187418 @default.
• W1974536241 cites W3002740628 @default.
• W1974536241 doi "https://doi.org/10.1111/j.1476-5381.1993.tb13588.x" @default.
• W1974536241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2175675" @default.
• W1974536241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8395288" @default.
• W1974536241 hasPublicationYear "1993" @default.
• W1974536241 type Work @default.
• W1974536241 sameAs 1974536241 @default.
• W1974536241 citedByCount "3" @default.
• W1974536241 countsByYear W19745362412015 @default.
• W1974536241 crossrefType "journal-article" @default.
• W1974536241 hasAuthorship W1974536241A5006330314 @default.
• W1974536241 hasAuthorship W1974536241A5011577349 @default.
• W1974536241 hasAuthorship W1974536241A5080135978 @default.
• W1974536241 hasAuthorship W1974536241A5089868099 @default.
• W1974536241 hasBestOaLocation W19745362412 @default.
• W1974536241 hasConcept C107824862 @default.
• W1974536241 hasConcept C12554922 @default.
• W1974536241 hasConcept C126322002 @default.
• W1974536241 hasConcept C134018914 @default.
• W1974536241 hasConcept C148762608 @default.
• W1974536241 hasConcept C168258287 @default.
• W1974536241 hasConcept C170493617 @default.
• W1974536241 hasConcept C185592680 @default.
• W1974536241 hasConcept C2776175493 @default.
• W1974536241 hasConcept C2779715522 @default.
• W1974536241 hasConcept C2780222073 @default.
• W1974536241 hasConcept C2781161787 @default.
• W1974536241 hasConcept C2781442855 @default.
• W1974536241 hasConcept C529278444 @default.
• W1974536241 hasConcept C541997718 @default.
• W1974536241 hasConcept C55493867 @default.
• W1974536241 hasConcept C71924100 @default.
• W1974536241 hasConcept C86803240 @default.
• W1974536241 hasConcept C98274493 @default.
• W1974536241 hasConceptScore W1974536241C107824862 @default.
• W1974536241 hasConceptScore W1974536241C12554922 @default.
• W1974536241 hasConceptScore W1974536241C126322002 @default.
• W1974536241 hasConceptScore W1974536241C134018914 @default.
• W1974536241 hasConceptScore W1974536241C148762608 @default.
• W1974536241 hasConceptScore W1974536241C168258287 @default.
• W1974536241 hasConceptScore W1974536241C170493617 @default.
• W1974536241 hasConceptScore W1974536241C185592680 @default.
• W1974536241 hasConceptScore W1974536241C2776175493 @default.
• W1974536241 hasConceptScore W1974536241C2779715522 @default.
• W1974536241 hasConceptScore W1974536241C2780222073 @default.
• W1974536241 hasConceptScore W1974536241C2781161787 @default.
• W1974536241 hasConceptScore W1974536241C2781442855 @default.
• W1974536241 hasConceptScore W1974536241C529278444 @default.
• W1974536241 hasConceptScore W1974536241C541997718 @default.
• W1974536241 hasConceptScore W1974536241C55493867 @default.
• W1974536241 hasConceptScore W1974536241C71924100 @default.

• next