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- W1974539462 abstract "A partial recovery of ultraviolet (U.V., 254 nm) induced petite mutation (ϱ−) is observed in exponential phase yeast. This process requires a period of dark holding (LH) in non-nutrient medium followed by growth in nutrient medium. At intervals during LH prelabelled DNA was examined by equilibrium cesium chloride gradients. The gradual decrease in ϱ− was accompanied by an ongoing degradation of mitochondrial DNA (mitDNA) during the first 24 hours followed by a stabilization. The dose response for mitDNA degradation was biphasic. No new synthesis of mitDNA occured during LH. MitDNA remaiting after degradation showed a) slight shift to a heavier buoyant density indicating a possible selective degradation of A-T regions b) no difference in size when compared to non-irradiated samples. The first step in the recovery of the ϱ− mutation is mitDNA degradation followed by other events taking place when growth resumes." @default.
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- W1974539462 date "1978-03-01" @default.
- W1974539462 modified "2023-09-28" @default.
- W1974539462 title "The fate of yeast mitochondrial DNA after ultraviolet irradiation I. Degradation during post-UV dark liquid holding in non-nutrient medium" @default.
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- W1974539462 doi "https://doi.org/10.1016/0006-291x(78)91531-0" @default.
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