FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974540299> ?p ?o ?g. }

• W1974540299 endingPage "148" @default.
• W1974540299 startingPage "S" @default.
• W1974540299 abstract "The purpose of this research was to investigate the role of neurogenic involvement in the etiopathogenesis of ocular surface inflammation, with the final goal of identifying new potential anti-inflammatory agents. We describe the presence of two “classic” markers of inflammation (HLA-DR and ICAM-1) and some neuroreceptors in cultured human conjunctival epithelial cells under basal and pro-inflammatory conditions. Two markers of inflammation (HLA-DR, ICAM-1) and several neuroreceptor subtypes (M1-, M2-, and M3-muscarinic; α1A-, α1B-, α1D-, α2A-, α2B-, α2C-, β1-, β2-, and β3-adrenergic) were analyzed in a normal human conjunctival epithelial cell line (IOBA-NHC). These markers were studied in basal conditions and under the influence of two pro-inflammatory cytokines: tumor necrosis factor alpha (TNF-α) and/or interferon gamma (IFN-γ). Immuno-fluorescence (confocal microscopy), western blotting, or flow cytometry techniques were used. In basal conditions, epithelial cells expressed all inflammatory markers except HLA-DR. The addition of IFN-γ enhanced expression of HLA-DR, ICAM-1, and M2-muscarinic receptor. TNF-α up-regulated the expression of ICAM-1. When epithelial cells were incubated in the presence of both cytokines together, the cell surface expression of HLA-DR, ICAM-1, α1B-, and α2B-adrenergic receptors was increased. Cultured human conjunctival epithelial cells have been shown to be susceptible to up-regulation of the expression of inflammatory markers and cell membrane expression of some neuroreceptors under pro-inflammatory conditions. Consequently, pharmacologic neuromodulation could have a role in the comprehensive management of ocular surface inflammation." @default.
• W1974540299 created "2016-06-24" @default.
• W1974540299 creator A5000593371 @default.
• W1974540299 creator A5002262449 @default.
• W1974540299 creator A5012646123 @default.
• W1974540299 creator A5024092541 @default.
• W1974540299 creator A5041033774 @default.
• W1974540299 creator A5054472871 @default.
• W1974540299 creator A5089346819 @default.
• W1974540299 date "2005-10-01" @default.
• W1974540299 modified "2023-10-17" @default.
• W1974540299 title "Variation in the Expression of Inflammatory Markers and Neuroreceptors in Human Conjunctival Epithelial Cells" @default.
• W1974540299 cites W1548605804 @default.
• W1974540299 cites W1615447620 @default.
• W1974540299 cites W1672814326 @default.
• W1974540299 cites W1971684362 @default.
• W1974540299 cites W1973462155 @default.
• W1974540299 cites W1983330051 @default.
• W1974540299 cites W1984943615 @default.
• W1974540299 cites W1989094823 @default.
• W1974540299 cites W1999062564 @default.
• W1974540299 cites W2008090567 @default.
• W1974540299 cites W2017757387 @default.
• W1974540299 cites W2018160598 @default.
• W1974540299 cites W2024921065 @default.
• W1974540299 cites W2025829142 @default.
• W1974540299 cites W2028033611 @default.
• W1974540299 cites W2036170000 @default.
• W1974540299 cites W2037537269 @default.
• W1974540299 cites W2053120464 @default.
• W1974540299 cites W2056768166 @default.
• W1974540299 cites W2066609350 @default.
• W1974540299 cites W2087540956 @default.
• W1974540299 cites W2090621408 @default.
• W1974540299 cites W2099756346 @default.
• W1974540299 cites W2125293769 @default.
• W1974540299 cites W2126358511 @default.
• W1974540299 cites W2135917172 @default.
• W1974540299 cites W2143112599 @default.
• W1974540299 cites W2144859953 @default.
• W1974540299 cites W2146310002 @default.
• W1974540299 cites W2188999903 @default.
• W1974540299 cites W2884740196 @default.
• W1974540299 doi "https://doi.org/10.1016/s1542-0124(12)70241-0" @default.
• W1974540299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17216105" @default.
• W1974540299 hasPublicationYear "2005" @default.
• W1974540299 type Work @default.
• W1974540299 sameAs 1974540299 @default.
• W1974540299 citedByCount "6" @default.
• W1974540299 countsByYear W19745402992018 @default.
• W1974540299 crossrefType "journal-article" @default.
• W1974540299 hasAuthorship W1974540299A5000593371 @default.
• W1974540299 hasAuthorship W1974540299A5002262449 @default.
• W1974540299 hasAuthorship W1974540299A5012646123 @default.
• W1974540299 hasAuthorship W1974540299A5024092541 @default.
• W1974540299 hasAuthorship W1974540299A5041033774 @default.
• W1974540299 hasAuthorship W1974540299A5054472871 @default.
• W1974540299 hasAuthorship W1974540299A5089346819 @default.
• W1974540299 hasConcept C126322002 @default.
• W1974540299 hasConcept C142724271 @default.
• W1974540299 hasConcept C147483822 @default.
• W1974540299 hasConcept C164027704 @default.
• W1974540299 hasConcept C170493617 @default.
• W1974540299 hasConcept C17991360 @default.
• W1974540299 hasConcept C203014093 @default.
• W1974540299 hasConcept C2776914184 @default.
• W1974540299 hasConcept C2779067128 @default.
• W1974540299 hasConcept C553184892 @default.
• W1974540299 hasConcept C71924100 @default.
• W1974540299 hasConcept C86803240 @default.
• W1974540299 hasConcept C95444343 @default.
• W1974540299 hasConceptScore W1974540299C126322002 @default.
• W1974540299 hasConceptScore W1974540299C142724271 @default.
• W1974540299 hasConceptScore W1974540299C147483822 @default.
• W1974540299 hasConceptScore W1974540299C164027704 @default.
• W1974540299 hasConceptScore W1974540299C170493617 @default.
• W1974540299 hasConceptScore W1974540299C17991360 @default.
• W1974540299 hasConceptScore W1974540299C203014093 @default.
• W1974540299 hasConceptScore W1974540299C2776914184 @default.
• W1974540299 hasConceptScore W1974540299C2779067128 @default.
• W1974540299 hasConceptScore W1974540299C553184892 @default.
• W1974540299 hasConceptScore W1974540299C71924100 @default.
• W1974540299 hasConceptScore W1974540299C86803240 @default.
• W1974540299 hasConceptScore W1974540299C95444343 @default.
• W1974540299 hasIssue "4" @default.
• W1974540299 hasLocation W19745402991 @default.
• W1974540299 hasLocation W19745402992 @default.
• W1974540299 hasOpenAccess W1974540299 @default.
• W1974540299 hasPrimaryLocation W19745402991 @default.
• W1974540299 hasRelatedWork W1992848314 @default.
• W1974540299 hasRelatedWork W2011724047 @default.
• W1974540299 hasRelatedWork W2015667478 @default.
• W1974540299 hasRelatedWork W2061613789 @default.
• W1974540299 hasRelatedWork W2392126385 @default.
• W1974540299 hasRelatedWork W2416795054 @default.
• W1974540299 hasRelatedWork W2571013527 @default.
• W1974540299 hasRelatedWork W2944714515 @default.
• W1974540299 hasRelatedWork W3039146159 @default.

• next