Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974546250> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1974546250 abstract "Regulated endocytic trafficking is the central mechanism facilitating a variety of neuromodulatory events, by dynamically controlling receptor, ion channel, and transporter cell surface presentation on a minutes time scale. There is a broad diversity of mechanisms that control endocytic trafficking of individual proteins. Studies investigating the molecular underpinnings of trafficking have primarily relied upon surface biotinylation to quantitatively measure changes in membrane protein surface expression in response to exogenous stimuli and gene manipulation. However, this approach has been mainly limited to cultured cells, which may not faithfully reflect the physiologically relevant mechanisms at play in adult neurons. Moreover, cultured cell approaches may underestimate region-specific differences in trafficking mechanisms. Here, we describe an approach that extends cell surface biotinylation to the acute brain slice preparation. We demonstrate that this method provides a high-fidelity approach to measure rapid changes in membrane protein surface levels in adult neurons. This approach is likely to have broad utility in the field of neuronal endocytic trafficking." @default.
- W1974546250 created "2016-06-24" @default.
- W1974546250 creator A5016284485 @default.
- W1974546250 creator A5016387090 @default.
- W1974546250 creator A5083630211 @default.
- W1974546250 date "2014-04-03" @default.
- W1974546250 modified "2023-10-01" @default.
- W1974546250 title "Brain Slice Biotinylation: An <em>Ex Vivo</em> Approach to Measure Region-specific Plasma Membrane Protein Trafficking in Adult Neurons" @default.
- W1974546250 cites W1657446979 @default.
- W1974546250 cites W1920778929 @default.
- W1974546250 cites W1923888830 @default.
- W1974546250 cites W1965507972 @default.
- W1974546250 cites W1970249278 @default.
- W1974546250 cites W1972596224 @default.
- W1974546250 cites W1984711181 @default.
- W1974546250 cites W1993721193 @default.
- W1974546250 cites W1995680954 @default.
- W1974546250 cites W2006241634 @default.
- W1974546250 cites W2022292972 @default.
- W1974546250 cites W2037820041 @default.
- W1974546250 cites W2044920235 @default.
- W1974546250 cites W2066577814 @default.
- W1974546250 cites W2067087475 @default.
- W1974546250 cites W2093414544 @default.
- W1974546250 cites W2123764853 @default.
- W1974546250 cites W2124009392 @default.
- W1974546250 cites W2128574573 @default.
- W1974546250 cites W2132099317 @default.
- W1974546250 cites W2153998371 @default.
- W1974546250 cites W2158551553 @default.
- W1974546250 cites W2167806590 @default.
- W1974546250 cites W2170248971 @default.
- W1974546250 doi "https://doi.org/10.3791/51240" @default.
- W1974546250 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4161274" @default.
- W1974546250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24747337" @default.
- W1974546250 hasPublicationYear "2014" @default.
- W1974546250 type Work @default.
- W1974546250 sameAs 1974546250 @default.
- W1974546250 citedByCount "23" @default.
- W1974546250 countsByYear W19745462502015 @default.
- W1974546250 countsByYear W19745462502017 @default.
- W1974546250 countsByYear W19745462502018 @default.
- W1974546250 countsByYear W19745462502020 @default.
- W1974546250 countsByYear W19745462502021 @default.
- W1974546250 countsByYear W19745462502022 @default.
- W1974546250 countsByYear W19745462502023 @default.
- W1974546250 crossrefType "journal-article" @default.
- W1974546250 hasAuthorship W1974546250A5016284485 @default.
- W1974546250 hasAuthorship W1974546250A5016387090 @default.
- W1974546250 hasAuthorship W1974546250A5083630211 @default.
- W1974546250 hasBestOaLocation W19745462502 @default.
- W1974546250 hasConcept C144647389 @default.
- W1974546250 hasConcept C1491633281 @default.
- W1974546250 hasConcept C153911025 @default.
- W1974546250 hasConcept C169760540 @default.
- W1974546250 hasConcept C170493617 @default.
- W1974546250 hasConcept C204628709 @default.
- W1974546250 hasConcept C28005876 @default.
- W1974546250 hasConcept C41625074 @default.
- W1974546250 hasConcept C50254741 @default.
- W1974546250 hasConcept C55493867 @default.
- W1974546250 hasConcept C57581600 @default.
- W1974546250 hasConcept C79747257 @default.
- W1974546250 hasConcept C86803240 @default.
- W1974546250 hasConcept C95444343 @default.
- W1974546250 hasConceptScore W1974546250C144647389 @default.
- W1974546250 hasConceptScore W1974546250C1491633281 @default.
- W1974546250 hasConceptScore W1974546250C153911025 @default.
- W1974546250 hasConceptScore W1974546250C169760540 @default.
- W1974546250 hasConceptScore W1974546250C170493617 @default.
- W1974546250 hasConceptScore W1974546250C204628709 @default.
- W1974546250 hasConceptScore W1974546250C28005876 @default.
- W1974546250 hasConceptScore W1974546250C41625074 @default.
- W1974546250 hasConceptScore W1974546250C50254741 @default.
- W1974546250 hasConceptScore W1974546250C55493867 @default.
- W1974546250 hasConceptScore W1974546250C57581600 @default.
- W1974546250 hasConceptScore W1974546250C79747257 @default.
- W1974546250 hasConceptScore W1974546250C86803240 @default.
- W1974546250 hasConceptScore W1974546250C95444343 @default.
- W1974546250 hasIssue "86" @default.
- W1974546250 hasLocation W19745462501 @default.
- W1974546250 hasLocation W19745462502 @default.
- W1974546250 hasLocation W19745462503 @default.
- W1974546250 hasLocation W19745462504 @default.
- W1974546250 hasOpenAccess W1974546250 @default.
- W1974546250 hasPrimaryLocation W19745462501 @default.
- W1974546250 hasRelatedWork W1898108646 @default.
- W1974546250 hasRelatedWork W1965248687 @default.
- W1974546250 hasRelatedWork W1986950157 @default.
- W1974546250 hasRelatedWork W2053132501 @default.
- W1974546250 hasRelatedWork W2092574969 @default.
- W1974546250 hasRelatedWork W2093719268 @default.
- W1974546250 hasRelatedWork W2133987610 @default.
- W1974546250 hasRelatedWork W2144560085 @default.
- W1974546250 hasRelatedWork W2914521507 @default.
- W1974546250 hasRelatedWork W3047443145 @default.
- W1974546250 isParatext "false" @default.
- W1974546250 isRetracted "false" @default.
- W1974546250 magId "1974546250" @default.
- W1974546250 workType "article" @default.