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- W1974547730 abstract "The formation of skeletal muscle is a tightly regulated process that is critically modulated by Wnt signaling. Myogenesis is dependent on the precise and dynamic integration of multiple Wnt signals allowing self-renewal and progression of muscle precursors in the myogenic lineage. Dysregulation of Wnt signaling can lead to severe developmental defects and perturbation of muscle homeostasis. Recent work has revealed novel roles for the non-canonical planar cell polarity (PCP) and AKT/mTOR pathways in mediating the effects of Wnt on skeletal muscle. In this review, we discuss the role of Wnt signaling in myogenesis and in regulating the homeostasis of adult muscle. The formation of skeletal muscle is a tightly regulated process that is critically modulated by Wnt signaling. Myogenesis is dependent on the precise and dynamic integration of multiple Wnt signals allowing self-renewal and progression of muscle precursors in the myogenic lineage. Dysregulation of Wnt signaling can lead to severe developmental defects and perturbation of muscle homeostasis. Recent work has revealed novel roles for the non-canonical planar cell polarity (PCP) and AKT/mTOR pathways in mediating the effects of Wnt on skeletal muscle. In this review, we discuss the role of Wnt signaling in myogenesis and in regulating the homeostasis of adult muscle. a dorsal–lateral sheet during embryogenesis that gives rise to skeletal muscle and the dermis. a family of seven-pass transmembrane receptors for Wnt ligands. coreceptor of Fzd in canonical Wnt signaling. an increase in myofiber size, either with or without addition of new myonuclei. skeletal muscle precursor cells that can differentiate into myocytes and further into myotubes. a multinucleated muscle cell that contracts on stimulation. the process of functional muscle formation. adult stem cells of skeletal muscle. the process by which a stem cell gives rise to an identical daughter cell, through symmetric or asymmetric division. a bilaterally paired structure during embryogenesis that gives rise to adult skeletal muscle and skeleton. a family of highly conserved secreted signaling molecules that typically bind to Fzd receptors." @default.
- W1974547730 created "2016-06-24" @default.
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- W1974547730 date "2012-11-01" @default.
- W1974547730 modified "2023-10-14" @default.
- W1974547730 title "Wnt signaling in myogenesis" @default.
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- W1974547730 doi "https://doi.org/10.1016/j.tcb.2012.07.008" @default.
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