Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974548098> ?p ?o ?g. }
- W1974548098 endingPage "e86495" @default.
- W1974548098 startingPage "e86495" @default.
- W1974548098 abstract "Oligomeric aggregates are widely suspected as toxic agents in diseases caused by protein aggregation, yet they remain poorly characterized, partly because they are challenging to isolate from a heterogeneous mixture of species. We developed an assay for characterizing structure, stability, and kinetics of individual oligomers at high resolution and sensitivity using single-molecule force spectroscopy, and applied it to observe the formation of transient structured aggregates within single oligomers of α-synuclein, an intrinsically-disordered protein linked to Parkinson’s disease. Measurements of the molecular extension as the proteins unfolded under tension in optical tweezers revealed that even small oligomers could form numerous metastable structures, with a surprisingly broad range of sizes. Comparing the structures formed in monomers, dimers and tetramers, we found that the average mechanical stability increased with oligomer size. Most structures formed within a minute, with size-dependent rates. These results provide a new window onto the complex α-synuclein aggregation landscape, characterizing the microscopic structural heterogeneity and kinetics of different pathways." @default.
- W1974548098 created "2016-06-24" @default.
- W1974548098 creator A5022834816 @default.
- W1974548098 creator A5051177940 @default.
- W1974548098 creator A5068089632 @default.
- W1974548098 creator A5073306543 @default.
- W1974548098 creator A5089565603 @default.
- W1974548098 date "2014-01-24" @default.
- W1974548098 modified "2023-09-27" @default.
- W1974548098 title "Diverse Metastable Structures Formed by Small Oligomers of α-Synuclein Probed by Force Spectroscopy" @default.
- W1974548098 cites W1680110353 @default.
- W1974548098 cites W1971281089 @default.
- W1974548098 cites W1976009604 @default.
- W1974548098 cites W1980859519 @default.
- W1974548098 cites W1983362126 @default.
- W1974548098 cites W1995248194 @default.
- W1974548098 cites W1998596396 @default.
- W1974548098 cites W2000654975 @default.
- W1974548098 cites W2001722542 @default.
- W1974548098 cites W2002559713 @default.
- W1974548098 cites W2006356944 @default.
- W1974548098 cites W2007374102 @default.
- W1974548098 cites W2007635840 @default.
- W1974548098 cites W2016433852 @default.
- W1974548098 cites W2016875890 @default.
- W1974548098 cites W2018633688 @default.
- W1974548098 cites W2019521349 @default.
- W1974548098 cites W2019877102 @default.
- W1974548098 cites W2021938401 @default.
- W1974548098 cites W2021977313 @default.
- W1974548098 cites W2023023883 @default.
- W1974548098 cites W2024182439 @default.
- W1974548098 cites W2026717532 @default.
- W1974548098 cites W2027402219 @default.
- W1974548098 cites W2028993667 @default.
- W1974548098 cites W2038225608 @default.
- W1974548098 cites W2041134571 @default.
- W1974548098 cites W2047348666 @default.
- W1974548098 cites W2049817931 @default.
- W1974548098 cites W2049827200 @default.
- W1974548098 cites W2050799629 @default.
- W1974548098 cites W2052660967 @default.
- W1974548098 cites W2054868321 @default.
- W1974548098 cites W2055067588 @default.
- W1974548098 cites W2055566196 @default.
- W1974548098 cites W2058912578 @default.
- W1974548098 cites W2063274771 @default.
- W1974548098 cites W2063616898 @default.
- W1974548098 cites W2072785240 @default.
- W1974548098 cites W2077881833 @default.
- W1974548098 cites W2080148133 @default.
- W1974548098 cites W2080751623 @default.
- W1974548098 cites W2082923159 @default.
- W1974548098 cites W2084670683 @default.
- W1974548098 cites W2089518281 @default.
- W1974548098 cites W2096573717 @default.
- W1974548098 cites W2100596347 @default.
- W1974548098 cites W2101298197 @default.
- W1974548098 cites W2102074396 @default.
- W1974548098 cites W2104400769 @default.
- W1974548098 cites W2107036307 @default.
- W1974548098 cites W2108587019 @default.
- W1974548098 cites W2112232744 @default.
- W1974548098 cites W2114229182 @default.
- W1974548098 cites W2115425931 @default.
- W1974548098 cites W2117481749 @default.
- W1974548098 cites W2129583700 @default.
- W1974548098 cites W2130323165 @default.
- W1974548098 cites W2130573743 @default.
- W1974548098 cites W2134141880 @default.
- W1974548098 cites W2138711764 @default.
- W1974548098 cites W2139433006 @default.
- W1974548098 cites W2139770018 @default.
- W1974548098 cites W2144737808 @default.
- W1974548098 cites W2145170797 @default.
- W1974548098 cites W2155477793 @default.
- W1974548098 cites W2158977717 @default.
- W1974548098 cites W2165186407 @default.
- W1974548098 cites W2165901553 @default.
- W1974548098 cites W2319107269 @default.
- W1974548098 cites W234859805 @default.
- W1974548098 cites W4211178136 @default.
- W1974548098 doi "https://doi.org/10.1371/journal.pone.0086495" @default.
- W1974548098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3901707" @default.
- W1974548098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24475132" @default.
- W1974548098 hasPublicationYear "2014" @default.
- W1974548098 type Work @default.
- W1974548098 sameAs 1974548098 @default.
- W1974548098 citedByCount "52" @default.
- W1974548098 countsByYear W19745480982014 @default.
- W1974548098 countsByYear W19745480982015 @default.
- W1974548098 countsByYear W19745480982016 @default.
- W1974548098 countsByYear W19745480982017 @default.
- W1974548098 countsByYear W19745480982018 @default.
- W1974548098 countsByYear W19745480982019 @default.
- W1974548098 countsByYear W19745480982020 @default.
- W1974548098 countsByYear W19745480982021 @default.
- W1974548098 countsByYear W19745480982022 @default.