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- W1974548150 abstract "Great scientifi c successes have been achieved over the past decade in the prevention of mother-to-child transmission (MTCT) of HIV with the development of eff ective antiretroviral interventions. 1 Initially, prevention of MTCT emphasised the use of antiretroviral therapy (ART) in women eligible for treatment for their own health. Pregnant women who are not eligible for such a treatment received short-course antiretroviral prophylaxis before and after birth and were encouraged to use alternatives to prolonged breastfeeding, such as replacement feeding or early breastfeeding cessation. However, these modifi ed infant feeding practices needed substantial care and nutritional counselling to be done safely and were therefore untenable at a population level. 2 Hence, prevention of HIV transmission through breastfeeding is a public health challenge, especially in sub-Saharan Africa where prolonged breastfeeding is a cultural norm. A new concept that might address MTCT in HIV-infected women with moderate to high CD4-cell counts is a triple antiretroviral prophylaxis during pregnancy and breastfeeding. 3 The Kesho Bora multicentre randomised trial, 4 in The Lancet Infectious Diseases, compares a triple antiretroviral prophylaxis strategy before and after birth with standard short-course antiretroviral regimen in HIVinfected women who are not eligible for ART for their own health. A 43% risk reduction of MTCT was shown at 12 months in the triple antiretroviral group compared with the standard short-course antiretroviral group, whereas the number of laboratory and clinical serious adverse events was similar in both groups. The results of the Kesho Bora trial, with those of other trials, 5,6" @default.
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- W1974548150 date "2011-03-01" @default.
- W1974548150 modified "2023-09-23" @default.
- W1974548150 title "Breastfeeding, triple ARV prophylaxis, and MTCT prevention" @default.
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- W1974548150 doi "https://doi.org/10.1016/s1473-3099(10)70299-1" @default.
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