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• W1974548916 abstract "A series of 2-substituted isothiazolo[5,4-b]pyridine-3(2H)-thiones, isothiazolo[5,4-b]pyridin-3(2H)-ones, N-substituted 2-sulfanylnicotinamides and the corresponding carbothioamide derivatives were synthesized and evaluated for their antimicrobial activity against several strains of Gram+ and Gram−bacteria and fungi. Chemical syntheses were resumed into a comprehensive cyclic route that enables the reversible conversion for each derivative of the series considered. Among the tested compounds the N-(aralkyl)-2-sulfanylnicotinamides show the highest fungitoxicity (MIC=1.25–5 μg/ml). The best activity towards Gram-positive bacteria was in the range of 2.5–5 μg/ml. Activity against Gram-negative bacteria was generally very poor for all compounds." @default.
• W1974548916 created "2016-06-24" @default.
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• W1974548916 date "2000-12-01" @default.
• W1974548916 modified "2023-09-26" @default.
• W1974548916 title "3H-[1,2]Dithiolo[3,4-b]pyridine-3-thione and its derivatives Synthesis and antimicrobial activity" @default.
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• W1974548916 doi "https://doi.org/10.1016/s0014-827x(00)00084-7" @default.
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