FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974548955> ?p ?o ?g. }

• W1974548955 endingPage "729" @default.
• W1974548955 startingPage "717" @default.
• W1974548955 abstract "Acid-sensing ion channels (ASICs) detect extracellular protons produced during inflammation or ischemic injury and belong to the superfamily of degenerin/epithelial sodium channels. Here, we determine the cocrystal structure of chicken ASIC1a with MitTx, a pain-inducing toxin from the Texas coral snake, to define the structure of the open state of ASIC1a. In the MitTx-bound open state and in the previously determined low-pH desensitized state, TM2 is a discontinuous α helix in which the Gly-Ala-Ser selectivity filter adopts an extended, belt-like conformation, swapping the cytoplasmic one-third of TM2 with an adjacent subunit. Gly 443 residues of the selectivity filter provide a ring of three carbonyl oxygen atoms with a radius of ∼3.6 Å, presenting an energetic barrier for hydrated ions. The ASIC1a-MitTx complex illuminates the mechanism of MitTx action, defines the structure of the selectivity filter of voltage-independent, sodium-selective ion channels, and captures the open state of an ASIC." @default.
• W1974548955 created "2016-06-24" @default.
• W1974548955 creator A5008840086 @default.
• W1974548955 creator A5010798355 @default.
• W1974548955 creator A5014886042 @default.
• W1974548955 creator A5085520710 @default.
• W1974548955 creator A5088125571 @default.
• W1974548955 date "2014-02-01" @default.
• W1974548955 modified "2023-10-15" @default.
• W1974548955 title "X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel" @default.
• W1974548955 cites W1502307422 @default.
• W1974548955 cites W1539796472 @default.
• W1974548955 cites W1597564353 @default.
• W1974548955 cites W1965498307 @default.
• W1974548955 cites W1967249092 @default.
• W1974548955 cites W1974642350 @default.
• W1974548955 cites W1983904542 @default.
• W1974548955 cites W1990955686 @default.
• W1974548955 cites W1991587021 @default.
• W1974548955 cites W1995665478 @default.
• W1974548955 cites W1996445293 @default.
• W1974548955 cites W2001295971 @default.
• W1974548955 cites W2001641653 @default.
• W1974548955 cites W2002976705 @default.
• W1974548955 cites W2004813038 @default.
• W1974548955 cites W2005960433 @default.
• W1974548955 cites W2006294085 @default.
• W1974548955 cites W2009199141 @default.
• W1974548955 cites W2013711061 @default.
• W1974548955 cites W2013973914 @default.
• W1974548955 cites W2014299900 @default.
• W1974548955 cites W2015971228 @default.
• W1974548955 cites W2016772559 @default.
• W1974548955 cites W2019839505 @default.
• W1974548955 cites W2026611274 @default.
• W1974548955 cites W2027089076 @default.
• W1974548955 cites W2028782030 @default.
• W1974548955 cites W2029582401 @default.
• W1974548955 cites W2034352765 @default.
• W1974548955 cites W2038618234 @default.
• W1974548955 cites W2038683056 @default.
• W1974548955 cites W2043901383 @default.
• W1974548955 cites W2050646232 @default.
• W1974548955 cites W2051237359 @default.
• W1974548955 cites W2058272504 @default.
• W1974548955 cites W2061408606 @default.
• W1974548955 cites W2062406801 @default.
• W1974548955 cites W2076667091 @default.
• W1974548955 cites W2079604571 @default.
• W1974548955 cites W2080550444 @default.
• W1974548955 cites W2083753650 @default.
• W1974548955 cites W2084923372 @default.
• W1974548955 cites W2085966270 @default.
• W1974548955 cites W2086688096 @default.
• W1974548955 cites W2090600102 @default.
• W1974548955 cites W2091510602 @default.
• W1974548955 cites W2093896324 @default.
• W1974548955 cites W2095818789 @default.
• W1974548955 cites W2096861046 @default.
• W1974548955 cites W2103558209 @default.
• W1974548955 cites W2106565954 @default.
• W1974548955 cites W2107701554 @default.
• W1974548955 cites W2109184569 @default.
• W1974548955 cites W2117003397 @default.
• W1974548955 cites W2122339645 @default.
• W1974548955 cites W2129631746 @default.
• W1974548955 cites W2129935026 @default.
• W1974548955 cites W2132665582 @default.
• W1974548955 cites W2134201060 @default.
• W1974548955 cites W2144081223 @default.
• W1974548955 cites W2144857888 @default.
• W1974548955 cites W2158888624 @default.
• W1974548955 cites W2160262877 @default.
• W1974548955 cites W2160398083 @default.
• W1974548955 cites W2168597484 @default.
• W1974548955 cites W4248872320 @default.
• W1974548955 cites W97009809 @default.
• W1974548955 doi "https://doi.org/10.1016/j.cell.2014.01.011" @default.
• W1974548955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4190031" @default.
• W1974548955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24507937" @default.
• W1974548955 hasPublicationYear "2014" @default.
• W1974548955 type Work @default.
• W1974548955 sameAs 1974548955 @default.
• W1974548955 citedByCount "249" @default.
• W1974548955 countsByYear W19745489552014 @default.
• W1974548955 countsByYear W19745489552015 @default.
• W1974548955 countsByYear W19745489552016 @default.
• W1974548955 countsByYear W19745489552017 @default.
• W1974548955 countsByYear W19745489552018 @default.
• W1974548955 countsByYear W19745489552019 @default.
• W1974548955 countsByYear W19745489552020 @default.
• W1974548955 countsByYear W19745489552021 @default.
• W1974548955 countsByYear W19745489552022 @default.
• W1974548955 countsByYear W19745489552023 @default.
• W1974548955 crossrefType "journal-article" @default.
• W1974548955 hasAuthorship W1974548955A5008840086 @default.
• W1974548955 hasAuthorship W1974548955A5010798355 @default.
• W1974548955 hasAuthorship W1974548955A5014886042 @default.

• next