FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974549830> ?p ?o ?g. }

• W1974549830 endingPage "71" @default.
• W1974549830 startingPage "63" @default.
• W1974549830 abstract "The major histocompatibility complex (MHC) class I chain-related A (MICA) gene, located near HLA-B, codes for protein products with structural similarities to those of classical MHC class I genes, but which neither bind β2-microglobulin nor present peptide. Expressed predominantly on gastrointestinal and tumour epithelial cells, they are stress-induced and interact with C-type lectin like receptor (NKG2D) on γδ, αβ CD8+ T cells and natural killer (NK) cells. MICA is highly polymorphic, with 54 extracellular allelic sequences described. We typed 200 healthy subjects in a sample of the São Paulo population by extended polymerase chain reaction–sequence-specific primers (PCR-SSP) to characterize the MICA polymorphism and analysed MICA/HLA-B linkage disequilibrium. The MICA*008 group (g) was predominant (47%), with several HLA-B associations. Rare combinations MICA*008g-HLA-B37, MICA*008g-B72 and MICA*010-HLA-B52 were detected. Given the extent of this polymorphism and its possible relevance for disease association, we determined MICA and HLA-B alleles in 33 Behçet's patients, in an attempt to clarify the associated genetic marker. Our results showed an increase of MICA*006, but not MICA*009, in the patient group (6/33) compared with controls (3/200) (18.2% vs. 1.5%; Pc = 0.005). Both alleles were always in association with HLA-B51, suggesting that HLA-B is indeed the primary susceptibility locus (P = 0.00008) and that MICA*006 may be an additional risk factor." @default.
• W1974549830 created "2016-06-24" @default.
• W1974549830 creator A5033255349 @default.
• W1974549830 creator A5040696650 @default.
• W1974549830 creator A5043944850 @default.
• W1974549830 creator A5062357257 @default.
• W1974549830 creator A5063315091 @default.
• W1974549830 date "2004-04-01" @default.
• W1974549830 modified "2023-09-26" @default.
• W1974549830 title "MICA polymorphism in a sample of the Sao Paulo population, Brazil" @default.
• W1974549830 cites W1532737852 @default.
• W1974549830 cites W1964066846 @default.
• W1974549830 cites W1964922876 @default.
• W1974549830 cites W1976510602 @default.
• W1974549830 cites W1984804980 @default.
• W1974549830 cites W1986044891 @default.
• W1974549830 cites W1993786192 @default.
• W1974549830 cites W1994474925 @default.
• W1974549830 cites W1998142458 @default.
• W1974549830 cites W1999341606 @default.
• W1974549830 cites W2000070744 @default.
• W1974549830 cites W2006202815 @default.
• W1974549830 cites W2010749951 @default.
• W1974549830 cites W2015325899 @default.
• W1974549830 cites W2023370541 @default.
• W1974549830 cites W2024742663 @default.
• W1974549830 cites W2030900629 @default.
• W1974549830 cites W2037310064 @default.
• W1974549830 cites W2037709997 @default.
• W1974549830 cites W2051550027 @default.
• W1974549830 cites W2064920472 @default.
• W1974549830 cites W2066902149 @default.
• W1974549830 cites W2067777120 @default.
• W1974549830 cites W2074807009 @default.
• W1974549830 cites W2076466010 @default.
• W1974549830 cites W2079030854 @default.
• W1974549830 cites W2080675233 @default.
• W1974549830 cites W2080873970 @default.
• W1974549830 cites W2081431255 @default.
• W1974549830 cites W2086553311 @default.
• W1974549830 cites W2120753117 @default.
• W1974549830 cites W2136038794 @default.
• W1974549830 cites W2170069789 @default.
• W1974549830 cites W4235673640 @default.
• W1974549830 cites W4243507883 @default.
• W1974549830 doi "https://doi.org/10.1111/j.1365-2370.2004.00446.x" @default.
• W1974549830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15086345" @default.
• W1974549830 hasPublicationYear "2004" @default.
• W1974549830 type Work @default.
• W1974549830 sameAs 1974549830 @default.
• W1974549830 citedByCount "31" @default.
• W1974549830 countsByYear W19745498302012 @default.
• W1974549830 countsByYear W19745498302014 @default.
• W1974549830 countsByYear W19745498302015 @default.
• W1974549830 countsByYear W19745498302016 @default.
• W1974549830 countsByYear W19745498302017 @default.
• W1974549830 countsByYear W19745498302018 @default.
• W1974549830 countsByYear W19745498302020 @default.
• W1974549830 countsByYear W19745498302022 @default.
• W1974549830 countsByYear W19745498302023 @default.
• W1974549830 crossrefType "journal-article" @default.
• W1974549830 hasAuthorship W1974549830A5033255349 @default.
• W1974549830 hasAuthorship W1974549830A5040696650 @default.
• W1974549830 hasAuthorship W1974549830A5043944850 @default.
• W1974549830 hasAuthorship W1974549830A5062357257 @default.
• W1974549830 hasAuthorship W1974549830A5063315091 @default.
• W1974549830 hasConcept C104317684 @default.
• W1974549830 hasConcept C147483822 @default.
• W1974549830 hasConcept C153911025 @default.
• W1974549830 hasConcept C154317977 @default.
• W1974549830 hasConcept C170627219 @default.
• W1974549830 hasConcept C180754005 @default.
• W1974549830 hasConcept C188280979 @default.
• W1974549830 hasConcept C197754878 @default.
• W1974549830 hasConcept C202751555 @default.
• W1974549830 hasConcept C203014093 @default.
• W1974549830 hasConcept C207936829 @default.
• W1974549830 hasConcept C2778867473 @default.
• W1974549830 hasConcept C2908647359 @default.
• W1974549830 hasConcept C35605836 @default.
• W1974549830 hasConcept C54355233 @default.
• W1974549830 hasConcept C71924100 @default.
• W1974549830 hasConcept C84597430 @default.
• W1974549830 hasConcept C86803240 @default.
• W1974549830 hasConcept C99454951 @default.
• W1974549830 hasConceptScore W1974549830C104317684 @default.
• W1974549830 hasConceptScore W1974549830C147483822 @default.
• W1974549830 hasConceptScore W1974549830C153911025 @default.
• W1974549830 hasConceptScore W1974549830C154317977 @default.
• W1974549830 hasConceptScore W1974549830C170627219 @default.
• W1974549830 hasConceptScore W1974549830C180754005 @default.
• W1974549830 hasConceptScore W1974549830C188280979 @default.
• W1974549830 hasConceptScore W1974549830C197754878 @default.
• W1974549830 hasConceptScore W1974549830C202751555 @default.
• W1974549830 hasConceptScore W1974549830C203014093 @default.
• W1974549830 hasConceptScore W1974549830C207936829 @default.
• W1974549830 hasConceptScore W1974549830C2778867473 @default.
• W1974549830 hasConceptScore W1974549830C2908647359 @default.

• next