Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974550609> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1974550609 endingPage "188" @default.
- W1974550609 startingPage "185" @default.
- W1974550609 abstract "OBJECTIVE--A pilot study to assess the efficacy of ICRF187 as a protective agent against the cardiotoxic effects of anthracycline drugs used to treat childhood malignancies. DESIGN--A study of cardiac function in children treated receiving ICRF187 ((s)-(+)-1,2 bis (3,5-dioxopiperazenyl) propane) in addition to anthracycline therapy compared with contemporary controls selected retrospectively on the basis of anthracycline dose matching. PATIENTS--Five children in whom recurrence of malignant disease was re-treated with chemotherapy containing anthracycline drugs and additional ICRF187 (supplied on a compassionate-use basis) (cumulative anthracycline doses 550-1650 mg/m2). Five more children with recurrence of malignant disease were re-treated to similar cumulative anthracycline doses (600-1150 mg/m2) without ICRF187. METHODS--Cardiac function was assessed clinically and echocardiographically throughout treatment. Clinical and echocardiographic state were compared before treatment and after completion of therapy within and between groups treated with and without ICRF187. RESULTS--Two patients treated without ICRF187 developed symptomatic congestive cardiac failure from which one died. Another developed considerable but as yet asymptomatic left ventricular dysfunction. No patient receiving additional ICRF187 developed cardiac failure or left ventricular dysfunction. There were no significant differences in cumulative anthracycline dose, dose increase, type of anthracycline used, survival rate, or length of survival between groups. Left ventricular shortening fraction fell by a mean of 1.0% in patients receiving ICRF187 and by a mean of 11% in the patients treated without it (p = 0.04). CONCLUSIONS--ICRF187 seems to have provided highly effective cardioprotection to this small group of children with end-stage malignancy. Severe cardiotoxicity was seen in a similar group treated with comparable anthracycline doses but without ICRF187." @default.
- W1974550609 created "2016-06-24" @default.
- W1974550609 creator A5041712070 @default.
- W1974550609 creator A5057384863 @default.
- W1974550609 creator A5068956531 @default.
- W1974550609 creator A5081646188 @default.
- W1974550609 creator A5088392347 @default.
- W1974550609 date "1993-08-01" @default.
- W1974550609 modified "2023-09-26" @default.
- W1974550609 title "Cardioprotection by ICRF187 against high dose anthracycline toxicity in children with malignant disease." @default.
- W1974550609 cites W1828224642 @default.
- W1974550609 cites W1969275339 @default.
- W1974550609 cites W1992786087 @default.
- W1974550609 cites W2018665136 @default.
- W1974550609 cites W2073912429 @default.
- W1974550609 cites W2091899293 @default.
- W1974550609 cites W2150376471 @default.
- W1974550609 doi "https://doi.org/10.1136/hrt.70.2.185" @default.
- W1974550609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1025283" @default.
- W1974550609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8038032" @default.
- W1974550609 hasPublicationYear "1993" @default.
- W1974550609 type Work @default.
- W1974550609 sameAs 1974550609 @default.
- W1974550609 citedByCount "67" @default.
- W1974550609 countsByYear W19745506092012 @default.
- W1974550609 countsByYear W19745506092014 @default.
- W1974550609 countsByYear W19745506092015 @default.
- W1974550609 countsByYear W19745506092016 @default.
- W1974550609 countsByYear W19745506092019 @default.
- W1974550609 countsByYear W19745506092020 @default.
- W1974550609 crossrefType "journal-article" @default.
- W1974550609 hasAuthorship W1974550609A5041712070 @default.
- W1974550609 hasAuthorship W1974550609A5057384863 @default.
- W1974550609 hasAuthorship W1974550609A5068956531 @default.
- W1974550609 hasAuthorship W1974550609A5081646188 @default.
- W1974550609 hasAuthorship W1974550609A5088392347 @default.
- W1974550609 hasBestOaLocation W19745506091 @default.
- W1974550609 hasConcept C111566952 @default.
- W1974550609 hasConcept C121608353 @default.
- W1974550609 hasConcept C126322002 @default.
- W1974550609 hasConcept C141071460 @default.
- W1974550609 hasConcept C151032500 @default.
- W1974550609 hasConcept C164705383 @default.
- W1974550609 hasConcept C2776694085 @default.
- W1974550609 hasConcept C2776802502 @default.
- W1974550609 hasConcept C2777910003 @default.
- W1974550609 hasConcept C2778198053 @default.
- W1974550609 hasConcept C2778233292 @default.
- W1974550609 hasConcept C2779399171 @default.
- W1974550609 hasConcept C530470458 @default.
- W1974550609 hasConcept C71924100 @default.
- W1974550609 hasConcept C78085059 @default.
- W1974550609 hasConceptScore W1974550609C111566952 @default.
- W1974550609 hasConceptScore W1974550609C121608353 @default.
- W1974550609 hasConceptScore W1974550609C126322002 @default.
- W1974550609 hasConceptScore W1974550609C141071460 @default.
- W1974550609 hasConceptScore W1974550609C151032500 @default.
- W1974550609 hasConceptScore W1974550609C164705383 @default.
- W1974550609 hasConceptScore W1974550609C2776694085 @default.
- W1974550609 hasConceptScore W1974550609C2776802502 @default.
- W1974550609 hasConceptScore W1974550609C2777910003 @default.
- W1974550609 hasConceptScore W1974550609C2778198053 @default.
- W1974550609 hasConceptScore W1974550609C2778233292 @default.
- W1974550609 hasConceptScore W1974550609C2779399171 @default.
- W1974550609 hasConceptScore W1974550609C530470458 @default.
- W1974550609 hasConceptScore W1974550609C71924100 @default.
- W1974550609 hasConceptScore W1974550609C78085059 @default.
- W1974550609 hasIssue "2" @default.
- W1974550609 hasLocation W19745506091 @default.
- W1974550609 hasLocation W19745506092 @default.
- W1974550609 hasLocation W19745506093 @default.
- W1974550609 hasLocation W19745506094 @default.
- W1974550609 hasOpenAccess W1974550609 @default.
- W1974550609 hasPrimaryLocation W19745506091 @default.
- W1974550609 hasRelatedWork W2042322799 @default.
- W1974550609 hasRelatedWork W2101382021 @default.
- W1974550609 hasRelatedWork W2108028042 @default.
- W1974550609 hasRelatedWork W2154213011 @default.
- W1974550609 hasRelatedWork W2363366439 @default.
- W1974550609 hasRelatedWork W2371199711 @default.
- W1974550609 hasRelatedWork W2501648659 @default.
- W1974550609 hasRelatedWork W2909980364 @default.
- W1974550609 hasRelatedWork W2915561147 @default.
- W1974550609 hasRelatedWork W2921504317 @default.
- W1974550609 hasVolume "70" @default.
- W1974550609 isParatext "false" @default.
- W1974550609 isRetracted "false" @default.
- W1974550609 magId "1974550609" @default.
- W1974550609 workType "article" @default.