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- W1974555308 abstract "As most transcription factors, GATA-1 activities are mediated by interactions with multiple proteins. Those identified so far associate with the zinc-finger domain and/or surrounding sequences. In contrast, no proteins interacting with the N-terminal domain have been identified although several evidences suggest its involvement in the control of hematopoiesis. In an attempt to identify proteins that interact with the N-terminal transactivation domain of GATA-1, a random phage peptide library was screened with recombinant GATA-1 protein and the sequence of a selected peptide was used for database protein sequence retrieval. We selected a set of peptides sharing the core sequence φ–B(2–3)–ν(2–4) (where φ, B, and ν represent hydrophobic, basic, and neutral residues, respectively). Using the sequence of the most represented peptide (pep5) as query, we retrieved the HIV accessory protein Nef. We show that Nef binds GATA-1 and GATA-3 in vitro in virtue of its sequence homology with pep5." @default.
- W1974555308 created "2016-06-24" @default.
- W1974555308 creator A5049090479 @default.
- W1974555308 creator A5050840985 @default.
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- W1974555308 date "2003-06-01" @default.
- W1974555308 modified "2023-10-16" @default.
- W1974555308 title "Selection of peptides with affinity for the N-terminal domain of GATA-1: identification of a potential interacting protein" @default.
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- W1974555308 doi "https://doi.org/10.1016/s0006-291x(03)00897-0" @default.
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