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- W1974555596 abstract "A novel, selective labeling of oligonucleotides with two different reporter groups is described. The oligonucleotide is synthesized using a stable 2-(4-methoxybenzamido)ethyl protection for a selected internucleosidic thiophosphate (PS) and a labile 2-(N-isopropyl-4-methoxybenzamido)ethyl for the 3‘-terminal PS and internucleosidic phosphates. The latter group and the base protection are removed, and the 3‘-terminal PS is labeled. The former protection is then cleaved by a prolonged ammonolysis, and the second reporter is introduced at the internucleosidic PS." @default.
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- W1974555596 date "2001-09-11" @default.
- W1974555596 modified "2023-10-16" @default.
- W1974555596 title "Selective Phosphate Protection: A Novel Synthesis of Double-Labeled Oligonucleotides" @default.
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- W1974555596 doi "https://doi.org/10.1021/ol016187w" @default.
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