FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974557172> ?p ?o ?g. }

• W1974557172 endingPage "147" @default.
• W1974557172 startingPage "139" @default.
• W1974557172 abstract "Benign prostatic hyperplasia (BPH) is an extremely common disease of older men in which there is benign overgrowth of the prostatic transition zone, leading to obstruction of urine outflow. Fibroblast growth factor (FGF) 2, a potent growth factor for prostatic stromal and epithelial cells, is increased twofold in BPH and its concentration is correlated with stromal proliferation in this condition. Immunohistochemistry of normal and hyperplastic prostate revealed that FGF2-expressing stromal cells were present in higher numbers near the epithelial acini, implying that epithelial cells may express a factor that induces FGF2 expression by stromal cells. Conditioned medium from primary cultures of prostatic epithelial cells was capable of inducing increased expression of FGF2 by primary stromal cultures. Blocking experiments with neutralizing anti-interleukin (IL)-8 antibodies and pretreatment with lipopolysaccharide, which down-regulates the IL-8 receptor, show that this inducing activity is because of the presence of IL-8 in the epithelial-conditioned medium. Analysis of normal prostatic peripheral zone and BPH tissue by enzyme-linked immunosorbent assay reveals that IL-8 is present at increased levels in hyperplastic prostate. Therefore IL-8 produced by prostatic epithelial cells can induce FGF2, a potent stromal and epithelial growth factor, and in this manner promote the abnormal proliferation of the prostatic transition zone that is critical in the pathogenesis of BPH." @default.
• W1974557172 created "2016-06-24" @default.
• W1974557172 creator A5042305007 @default.
• W1974557172 creator A5066263660 @default.
• W1974557172 date "2001-07-01" @default.
• W1974557172 modified "2023-09-27" @default.
• W1974557172 title "Interleukin-8 Is a Paracrine Inducer of Fibroblast Growth Factor 2, a Stromal and Epithelial Growth Factor in Benign Prostatic Hyperplasia" @default.
• W1974557172 cites W1505821987 @default.
• W1974557172 cites W1872583110 @default.
• W1974557172 cites W1949522388 @default.
• W1974557172 cites W1969997861 @default.
• W1974557172 cites W1976740313 @default.
• W1974557172 cites W1989866174 @default.
• W1974557172 cites W1995827621 @default.
• W1974557172 cites W2013608315 @default.
• W1974557172 cites W2021643561 @default.
• W1974557172 cites W2035982783 @default.
• W1974557172 cites W2038286433 @default.
• W1974557172 cites W2058712340 @default.
• W1974557172 cites W2058733999 @default.
• W1974557172 cites W2064531218 @default.
• W1974557172 cites W2068879625 @default.
• W1974557172 cites W2088635279 @default.
• W1974557172 cites W2090575954 @default.
• W1974557172 cites W2098499254 @default.
• W1974557172 cites W2106054588 @default.
• W1974557172 cites W2110669077 @default.
• W1974557172 cites W2128667036 @default.
• W1974557172 cites W2162638313 @default.
• W1974557172 cites W2166339022 @default.
• W1974557172 cites W2315389571 @default.
• W1974557172 cites W2400609040 @default.
• W1974557172 cites W2415764128 @default.
• W1974557172 doi "https://doi.org/10.1016/s0002-9440(10)61681-1" @default.
• W1974557172 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1850405" @default.
• W1974557172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11438462" @default.
• W1974557172 hasPublicationYear "2001" @default.
• W1974557172 type Work @default.
• W1974557172 sameAs 1974557172 @default.
• W1974557172 citedByCount "117" @default.
• W1974557172 countsByYear W19745571722012 @default.
• W1974557172 countsByYear W19745571722013 @default.
• W1974557172 countsByYear W19745571722014 @default.
• W1974557172 countsByYear W19745571722015 @default.
• W1974557172 countsByYear W19745571722016 @default.
• W1974557172 countsByYear W19745571722017 @default.
• W1974557172 countsByYear W19745571722018 @default.
• W1974557172 countsByYear W19745571722019 @default.
• W1974557172 countsByYear W19745571722020 @default.
• W1974557172 countsByYear W19745571722021 @default.
• W1974557172 countsByYear W19745571722022 @default.
• W1974557172 countsByYear W19745571722023 @default.
• W1974557172 crossrefType "journal-article" @default.
• W1974557172 hasAuthorship W1974557172A5042305007 @default.
• W1974557172 hasAuthorship W1974557172A5066263660 @default.
• W1974557172 hasBestOaLocation W19745571721 @default.
• W1974557172 hasConcept C121608353 @default.
• W1974557172 hasConcept C126322002 @default.
• W1974557172 hasConcept C134018914 @default.
• W1974557172 hasConcept C142724271 @default.
• W1974557172 hasConcept C16930146 @default.
• W1974557172 hasConcept C170493617 @default.
• W1974557172 hasConcept C2775960820 @default.
• W1974557172 hasConcept C2776235491 @default.
• W1974557172 hasConcept C2777562237 @default.
• W1974557172 hasConcept C2777587049 @default.
• W1974557172 hasConcept C2778690821 @default.
• W1974557172 hasConcept C502942594 @default.
• W1974557172 hasConcept C529295009 @default.
• W1974557172 hasConcept C71924100 @default.
• W1974557172 hasConcept C74373430 @default.
• W1974557172 hasConcept C7876069 @default.
• W1974557172 hasConcept C86803240 @default.
• W1974557172 hasConceptScore W1974557172C121608353 @default.
• W1974557172 hasConceptScore W1974557172C126322002 @default.
• W1974557172 hasConceptScore W1974557172C134018914 @default.
• W1974557172 hasConceptScore W1974557172C142724271 @default.
• W1974557172 hasConceptScore W1974557172C16930146 @default.
• W1974557172 hasConceptScore W1974557172C170493617 @default.
• W1974557172 hasConceptScore W1974557172C2775960820 @default.
• W1974557172 hasConceptScore W1974557172C2776235491 @default.
• W1974557172 hasConceptScore W1974557172C2777562237 @default.
• W1974557172 hasConceptScore W1974557172C2777587049 @default.
• W1974557172 hasConceptScore W1974557172C2778690821 @default.
• W1974557172 hasConceptScore W1974557172C502942594 @default.
• W1974557172 hasConceptScore W1974557172C529295009 @default.
• W1974557172 hasConceptScore W1974557172C71924100 @default.
• W1974557172 hasConceptScore W1974557172C74373430 @default.
• W1974557172 hasConceptScore W1974557172C7876069 @default.
• W1974557172 hasConceptScore W1974557172C86803240 @default.
• W1974557172 hasFunder F4320332161 @default.
• W1974557172 hasIssue "1" @default.
• W1974557172 hasLocation W19745571721 @default.
• W1974557172 hasLocation W19745571722 @default.
• W1974557172 hasLocation W19745571723 @default.
• W1974557172 hasLocation W19745571724 @default.
• W1974557172 hasOpenAccess W1974557172 @default.
• W1974557172 hasPrimaryLocation W19745571721 @default.

• next