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• W1974558512 abstract "The effects of interleukin 6 (IL-6), the major inducer of the acute-phase reaction, on the expression of inter-α-trypsin inhibitor (ITI) genes were examined using human HepG2 hepatoma cells. The three ITI heavy chain genes H1, H2 and H3 were transcriptionally regulated by IL-6 in a dose- and time-dependent manner. The treatment of HepG2 cells with IL-6 resulted in an increase of H1 and H3 mRNA levels and a decrease of H2 and L mRNA levels. Actinomycin D blocked the action of IL-6, suggesting that IL-6 regulated the H1, H2, H3 gene expression. Moreover, the kinetics of the ITI mRNA degradation in untreated and IL-6-treated cells confirmed these data. The nuclear run-on assay supports the regulatory effect of IL-6 at the transcription level of the L and H2 genes. Primer extension experiments showed that the effect of IL-6 on L, H2 and H3 mRNA synthesis was not related to the transcription starting point. Although H1, H2, H3 and L gene products are supposedly present in similar amounts in the ITI and pre-α-trypsin inhibitor molecules, the present work shows that these genes are regulated in a different manner, at least under the influence of IL-6." @default.
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• W1974558512 date "2008-06-28" @default.
• W1974558512 modified "2023-10-09" @default.
• W1974558512 title "The Human Inter-α-Trypsin Inhibitor Genes Respond Differently to Interleukin-6 in HepG2 Cells" @default.
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• W1974558512 doi "https://doi.org/10.1111/j.1432-1033.1995.0808p.x" @default.
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