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• W1974559069 abstract "<h3>Objectives</h3> To construct a risk score out of baseline variables to estimate the risk of death without prior implantable cardioverter defibrillator (ICD) in primary prevention ICD patients with ischaemic heart disease. <h3>Design</h3> Retrospective cohort study. <h3>Setting</h3> Tertiary care facility in The Netherlands. <h3>Patients</h3> All patients with ischaemic heart disease who received an ICD for primary prevention of sudden cardiac death at the Leiden University Medical Center, Leiden, The Netherlands in the period 1996–2009. <h3>Main outcome measure</h3> All-cause mortality without prior appropriate ICD therapy (anti-tachycardia pacing or shock). <h3>Results</h3> 900 patients (87% men, mean age 64±10 years) were included in the analysis. During a median follow-up of 669 days (IQR 363–1322 days), 150 patients (17%) died and 191 (21%) patients received appropriate device therapy. 114 (13%) patients died without prior appropriate therapy. Stratification of the risk for death without prior appropriate therapy resulted in risk categorisation of patients as low, intermediate or high risk. NYHA ≥III, advanced age, diabetes mellitus, left ventricular ejection fraction ≤25% and a history of smoking were significant independent predictors of death without appropriate ICD therapy. 5-year cumulative incidence for death without prior appropriate therapy ranged from 10% (95% CI 6% to 16%) in low-risk patients to 41% (95% CI 33% to 51%) in high-risk patients. <h3>Conclusions</h3> The risk of death without prior appropriate ICD therapy can be predicted in primary prevention ICD patients with ischaemic heart disease, which facilitates patient-tailored risk estimation." @default.
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• W1974559069 date "2012-05-12" @default.
• W1974559069 modified "2023-10-14" @default.
• W1974559069 title "Clinical prediction model for death prior to appropriate therapy in primary prevention implantable cardioverter defibrillator patients with ischaemic heart disease: the FADES risk score" @default.
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• W1974559069 doi "https://doi.org/10.1136/heartjnl-2011-300632" @default.
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