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• W1974563910 abstract "No AccessJournal of UrologyPediatric urology1 Apr 2008Partial Unilateral Ureteral Obstruction in Newborn Mice: Magnetic Resonance Imaging and Pathology Studies Florent Guerin, Robin Azoulay, Dominique Berrebi, Guy Sebag, Yves Aigrain, Michel Peuchmaur, and Alaa El-Ghoneimi Florent GuerinFlorent Guerin Department of Pediatric Surgery and Urology, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France Department of Pathology EA 3102, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France Microsurgery Laboratory, Agence Générale des Équipements et des Produits de Santé, Paris, France More articles by this author , Robin AzoulayRobin Azoulay Department of Pediatric Radiology, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France More articles by this author , Dominique BerrebiDominique Berrebi Department of Pathology EA 3102, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France More articles by this author , Guy SebagGuy Sebag Department of Pediatric Radiology, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France More articles by this author , Yves AigrainYves Aigrain Department of Pediatric Surgery and Urology, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France Department of Pathology EA 3102, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France Microsurgery Laboratory, Agence Générale des Équipements et des Produits de Santé, Paris, France More articles by this author , Michel PeuchmaurMichel Peuchmaur Department of Pathology EA 3102, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France More articles by this author , and Alaa El-GhoneimiAlaa El-Ghoneimi Department of Pediatric Surgery and Urology, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France Department of Pathology EA 3102, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2007.11.088AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The mechanism underlying the evolution of congenital obstructive hydronephrosis in humans is still unclear. Although partial unilateral ureteral obstruction has been extensively explored in rats, studies in neonatal mice may lead to new insights into underlying cellular mechanisms, especially with the availability of mutant mice. We developed a model of partial unilateral ureteral obstruction in newborn mice. Materials and Methods: Mice were operated on by the fifth day of life. We created 3 groups, namely partial unilateral ureteral obstruction (embedding the ureter in the psoas muscle), complete unilateral ureteral obstruction (ligating the ureter) and sham (exposing the ureter). We studied pelvis diameter and kidney length on magnetic resonance imaging, and kidney weight, inflammation, apoptosis and fibrosis on histological assessment during the second (early) and fourth weeks (late) postoperatively. Results: Magnetic resonance imaging showed enlarged pelvis diameter in late partial unilateral ureteral obstruction, and in early and late complete unilateral ureteral obstruction. Pathological studies revealed parenchyma atrophy in early and late partial unilateral ureteral obstruction. Apoptosis occurred early in partial unilateral ureteral obstruction and decreased later. Macrophage infiltration was enhanced in early and late partial unilateral ureteral obstruction. Fibrosis increased in late partial unilateral ureteral obstruction. All of these results were significantly intermediate between mice with complete unilateral ureteral obstruction and sham operated mice. Conclusions: It is possible to create renal lesions in newborn mice specific to partial ureteral obstruction. Magnetic resonance imaging of morphological changes demonstrated specific features of partial unilateral ureteral obstruction. Being noninvasive, this approach opens the way for further studies to investigate prognostic parameters after partial ureteral obstruction. In the future this model could be used in knockout mice to study the pathogenesis of renal lesions secondary to obstruction. 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Google Scholar © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4April 2008Page: 1553-1563 Advertisement Copyright & Permissions© 2008 by American Urological AssociationKeywordsnewbornanimalsmagnetic resonance imagingmiceureteral obstructionAcknowledgmentsDr. Blank, INSERM E0225, Medicine Faculty Bichat Claude Bernard, Paris, France, provided the anti-CD11b.MetricsAuthor Information Florent Guerin Department of Pediatric Surgery and Urology, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France Department of Pathology EA 3102, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France Microsurgery Laboratory, Agence Générale des Équipements et des Produits de Santé, Paris, France More articles by this author Robin Azoulay Department of Pediatric Radiology, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France More articles by this author Dominique Berrebi Department of Pathology EA 3102, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France More articles by this author Guy Sebag Department of Pediatric Radiology, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France More articles by this author Yves Aigrain Department of Pediatric Surgery and Urology, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France Department of Pathology EA 3102, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France Microsurgery Laboratory, Agence Générale des Équipements et des Produits de Santé, Paris, France More articles by this author Michel Peuchmaur Department of Pathology EA 3102, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France More articles by this author Alaa El-Ghoneimi Department of Pediatric Surgery and Urology, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France Department of Pathology EA 3102, Hôpital Robert Debré, APHP, University of Paris VII, René Diderot, Paris, France More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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