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• W1974564127 abstract "A replication-defective, acute transforming retrovirus (murine sarcoma virus 3611) was isolated from mouse and molecularly cloned. The nucleotide sequence of 1.5 kilobases encompassing the transforming gene (v-raf) was determined. This sequence, which predicts the amino acid sequence of a gag-raf fusion protein, terminates 180 nucleotides from the 3' end of the acquired cellular sequence. Comparison of the predicted amino acid sequence of v-raf with the predicted amino acid sequences of other oncogenes reveals significant homologies to the src family of oncogenes. There is a lack of homology within the sequence of the tyrosine acceptor domain described for the phosphotyrosine kinase members of the src family of transforming proteins. Phylogenetic arrangement of this family of oncogenes suggests that tyrosine-specific phosphorylation may be a recently acquired activity." @default.
• W1974564127 created "2016-06-24" @default.
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• W1974564127 date "1984-04-20" @default.
• W1974564127 modified "2023-09-23" @default.
• W1974564127 title "Primary Structure of v- <i>raf</i> : Relatedness to the <i>src</i> Family of Oncogenes" @default.
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• W1974564127 doi "https://doi.org/10.1126/science.6324342" @default.
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