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- W1974564452 abstract "Abstract The release of dopamine in the CNS by repeated doses of amphetamine is thought to underlie amphetamine-induced psychosis in humans and behavioural augmentation in experimental animals, although the mechanisms involved are incompletely understood. Donald Dougan, Denis Wade and Patricia Duffield discuss recent data on the long-term accumulation of metabolites of amphetamine in the brain. One of these compounds, α-methyltyramine, the para-hydroxylated metabolite of amphetamine, enhances the stereotype response to the acute administration of the drug and also causes augmentation of the amphetamine-induced decrease in dopamine metabolism in the striatum. These observations are consistent with the hypothesis that behavioural augmentation, seen after repeated doses of amphetamine, is due to the accumulation of α-methyltyramine in dopaminergic nerve terminals. Subsequent doses of amphetamine then release α-methyltyramine which blocks dopamine uptake with an apparent increase in the amphetamine-releasable pool of dopamine without change in receptor sensitivity. The close structural and metabolic similarities between amphetamine and its metabolites, and naturally occurring monoamines, again raises the question of the possible role of these amines in some forms of schizophrenia." @default.
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- W1974564452 date "1987-07-01" @default.
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- W1974564452 title "How metabolites may augment some psychostimulant actions of amphetamine" @default.
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- W1974564452 doi "https://doi.org/10.1016/0165-6147(87)90203-3" @default.
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