FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974567237> ?p ?o ?g. }

• W1974567237 endingPage "10370" @default.
• W1974567237 startingPage "10358" @default.
• W1974567237 abstract "Hef is an archaeal member of the DNA repair endonuclease XPF (XPF)/Crossover junction endonuclease MUS81 (MUS81)/Fanconi anemia, complementation group M (FANCM) protein family that in eukaryotes participates in the restart of stalled DNA replication forks. To investigate the physiological roles of Hef in maintaining genome stability in living archaeal cells, we studied the localization of Hef-green fluorescent protein fusions by fluorescence microscopy. Our studies revealed that Haloferax volcanii Hef proteins formed specific localization foci under regular growth conditions, the number of which specifically increased in response to replication arrest. Purification of the full-length Hef protein from its native host revealed that it forms a stable homodimer in solution, with a peculiar elongated configuration. Altogether our data indicate that the shape of Hef, significant physicochemical constraints and/or interactions with DNA limit the apparent cytosolic diffusion of halophilic DNA replication/repair complexes, and demonstrate that Hef proteins are dynamically recruited to archaeal eukaryotic-like chromatin to counteract DNA replication stress. We suggest that the evolutionary conserved function of Hef/FANCM proteins is to enhance replication fork stability by directly interacting with collapsed replication forks." @default.
• W1974567237 created "2016-06-24" @default.
• W1974567237 creator A5036466236 @default.
• W1974567237 creator A5058015886 @default.
• W1974567237 creator A5062554404 @default.
• W1974567237 creator A5070931980 @default.
• W1974567237 creator A5073366914 @default.
• W1974567237 creator A5083811720 @default.
• W1974567237 creator A5091789775 @default.
• W1974567237 date "2013-09-17" @default.
• W1974567237 modified "2023-10-01" @default.
• W1974567237 title "Intracellular dynamics of archaeal FANCM homologue Hef in response to halted DNA replication" @default.
• W1974567237 cites W1524728346 @default.
• W1974567237 cites W1971754542 @default.
• W1974567237 cites W1972116779 @default.
• W1974567237 cites W1975317507 @default.
• W1974567237 cites W1988822278 @default.
• W1974567237 cites W1991568949 @default.
• W1974567237 cites W1998491954 @default.
• W1974567237 cites W2000989488 @default.
• W1974567237 cites W2007703737 @default.
• W1974567237 cites W2016189813 @default.
• W1974567237 cites W2022460501 @default.
• W1974567237 cites W2022972203 @default.
• W1974567237 cites W2023336924 @default.
• W1974567237 cites W2027256377 @default.
• W1974567237 cites W2031753266 @default.
• W1974567237 cites W2047788174 @default.
• W1974567237 cites W2050630298 @default.
• W1974567237 cites W2060232836 @default.
• W1974567237 cites W2060924725 @default.
• W1974567237 cites W2063860903 @default.
• W1974567237 cites W2074273508 @default.
• W1974567237 cites W2087967916 @default.
• W1974567237 cites W2096402297 @default.
• W1974567237 cites W2102265131 @default.
• W1974567237 cites W2110519712 @default.
• W1974567237 cites W2112664493 @default.
• W1974567237 cites W2127678330 @default.
• W1974567237 cites W2139086659 @default.
• W1974567237 cites W2141539652 @default.
• W1974567237 cites W2150485014 @default.
• W1974567237 cites W2151487235 @default.
• W1974567237 cites W2156907859 @default.
• W1974567237 cites W2159656070 @default.
• W1974567237 cites W2166669307 @default.
• W1974567237 cites W2167813589 @default.
• W1974567237 cites W2171539493 @default.
• W1974567237 cites W2416808162 @default.
• W1974567237 doi "https://doi.org/10.1093/nar/gkt816" @default.
• W1974567237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3905845" @default.
• W1974567237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24049073" @default.
• W1974567237 hasPublicationYear "2013" @default.
• W1974567237 type Work @default.
• W1974567237 sameAs 1974567237 @default.
• W1974567237 citedByCount "21" @default.
• W1974567237 countsByYear W19745672372014 @default.
• W1974567237 countsByYear W19745672372015 @default.
• W1974567237 countsByYear W19745672372016 @default.
• W1974567237 countsByYear W19745672372017 @default.
• W1974567237 countsByYear W19745672372018 @default.
• W1974567237 countsByYear W19745672372020 @default.
• W1974567237 countsByYear W19745672372021 @default.
• W1974567237 countsByYear W19745672372022 @default.
• W1974567237 crossrefType "journal-article" @default.
• W1974567237 hasAuthorship W1974567237A5036466236 @default.
• W1974567237 hasAuthorship W1974567237A5058015886 @default.
• W1974567237 hasAuthorship W1974567237A5062554404 @default.
• W1974567237 hasAuthorship W1974567237A5070931980 @default.
• W1974567237 hasAuthorship W1974567237A5073366914 @default.
• W1974567237 hasAuthorship W1974567237A5083811720 @default.
• W1974567237 hasAuthorship W1974567237A5091789775 @default.
• W1974567237 hasBestOaLocation W19745672371 @default.
• W1974567237 hasConcept C104317684 @default.
• W1974567237 hasConcept C104690221 @default.
• W1974567237 hasConcept C113271649 @default.
• W1974567237 hasConcept C134935766 @default.
• W1974567237 hasConcept C149187182 @default.
• W1974567237 hasConcept C151158763 @default.
• W1974567237 hasConcept C175248279 @default.
• W1974567237 hasConcept C188036394 @default.
• W1974567237 hasConcept C54355233 @default.
• W1974567237 hasConcept C552990157 @default.
• W1974567237 hasConcept C58337764 @default.
• W1974567237 hasConcept C73573662 @default.
• W1974567237 hasConcept C86339819 @default.
• W1974567237 hasConcept C86803240 @default.
• W1974567237 hasConcept C94966510 @default.
• W1974567237 hasConcept C95444343 @default.
• W1974567237 hasConcept C98086919 @default.
• W1974567237 hasConceptScore W1974567237C104317684 @default.
• W1974567237 hasConceptScore W1974567237C104690221 @default.
• W1974567237 hasConceptScore W1974567237C113271649 @default.
• W1974567237 hasConceptScore W1974567237C134935766 @default.
• W1974567237 hasConceptScore W1974567237C149187182 @default.
• W1974567237 hasConceptScore W1974567237C151158763 @default.
• W1974567237 hasConceptScore W1974567237C175248279 @default.
• W1974567237 hasConceptScore W1974567237C188036394 @default.

• next