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- W1974567777 abstract "The stereoselective synthesis of structurally simplified heptacyclic cephalostatin analogues 2, 3, 18–21, 31, 32 and 33 by multiple Heck reactions is described. The key step of the synthesis is a selective Heck reaction of hydrindene 7 with 12 and 25, respectively at the vinyl bromide moiety followed by the introduction of a second molecule of 7 and a twofold intramolecular Heck reaction. The obtained bissteroidal heptacyclic compounds 2 and 3, in which the central octahydrophenazine moiety of 1 is replaced by a benzene ring, contain an unusual cis-annulation of the two newly generated rings. The cytotoxicity of some of the derivatives was determined on human lung cancer cell line A 549 in HTFCA tests (Human tumor colony forming ability). They show a rather high activity with an ED50 in the micro molar range." @default.
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- W1974567777 date "2002-05-03" @default.
- W1974567777 modified "2023-09-25" @default.
- W1974567777 title "Stereoselective Synthesis of Structurally Simplified Cephalostatin Analogues by Multiple Heck Reactions and Their Biological Evaluation" @default.
- W1974567777 doi "https://doi.org/10.1002/1521-3765(20020503)8:9<2116::aid-chem2116>3.0.co;2-4" @default.
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