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• W1974571161 abstract "The effects of majonoside-R2 on antinociceptive responses caused by the μ-opioid receptor agonist morphine and the selective κ-opioid receptor agonist U-50,488H were examined by the tail-pinch test in mice. Intraperitoneal (IP) or intracerebroventricular (ICV) injection of majonoside-R2 (3.1–6.2 mg/kg, IP or 5–10 μg/mouse, ICV) and diazepam (0.1–0.5 mg/kg, IP or 0.5–1.0 μg/mouse, ICV), as well as an opioid receptor antagonist naloxone (2 mg/kg, IP or 5 μg/mouse, ICV), dose-dependently attenuated the antinociception caused by subcutaneously administered morphine and U-50,488H. Moreover, when co-administered ICV or intrathecally (IT) with morphine (4 μg/mouse) or U-50,488H (60 μg/mouse), majonoside-R2 (5–20 μg/mouse) also exhibited antagonism against the antinociceptive action of these opioid receptor agonists in the tail-pinch test. The inhibitory effects of majonoside-R2 (10 μg/mouse, ICV) and diazepam (1 μg/mouse, ICV) were reversed by flumazenil (2.5 μg/mouse, ICV), a selective benzodiazepine receptor antagonist, and picrotoxin (0.25 μg/mouse, ICV), a GABA-gated chloride channel blocker. These results suggest that majonoside-R2 attenuates the opioid-induced antinociception by acting at the spinal and supraspinal levels, and that the GABAA receptor complex at the supraspinal level is involved in the effect of ICV administered majonoside-R2." @default.
• W1974571161 created "2016-06-24" @default.
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• W1974571161 date "1997-05-01" @default.
• W1974571161 modified "2023-10-18" @default.
• W1974571161 title "Majonoside-R2, a Major Constituent of Vietnamese Ginseng, Attenuates Opioid-induced Antinociception" @default.
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• W1974571161 doi "https://doi.org/10.1016/s0091-3057(96)00348-6" @default.
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