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- W1974575011 abstract "Cells in the basal metazoan phylum Cnidaria are characterized by remarkable plasticity in their differentiation capacity. The mechanism controlling asymmetric cell divisions is not understood in cnidarians or in any other animal group. PIWI proteins recently have been shown to be involved in maintaining the self-renewal capacity of stem cells in organisms as diverse as ciliates, flies, worms and mammals. Seipel et al.1 find that, in the cnidarian Podocoryne carnea, the Piwi homolog Cniwi is transcriptionally upregulated when the polyp generates buds, which will develop into medusae. Since transdifferentiation of striated muscle cells to smooth muscle cells also activated Cniwi expression, Cniwi appears to play a crucial role in differentiation events. The discovery should facilitate elucidation of the poorly understood factors that control asymmetric cell divisions at the beginning of animal evolution. BioEssays 26:929–931, 2004. © 2004 Wiley Periodicals, Inc." @default.
- W1974575011 created "2016-06-24" @default.
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- W1974575011 date "2004-01-01" @default.
- W1974575011 modified "2023-09-23" @default.
- W1974575011 title "Control of asymmetric cell divisions: will cnidarians provide an answer?" @default.
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- W1974575011 doi "https://doi.org/10.1002/bies.20108" @default.
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