Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974576586> ?p ?o ?g. }
- W1974576586 endingPage "135" @default.
- W1974576586 startingPage "121" @default.
- W1974576586 abstract "An aversive tobacco abstinence syndrome, thought to reflect an underlying level of nicotine dependence, contributes to cigarette smokers' failed quit attempts. Nicotine replacement therapy (NRT) suppresses tobacco abstinence, but high relapse rates suggest room for improvement. Improving NRT's efficacy might begin with identifying factors that influence tobacco abstinence symptom suppression. Two such factors are smokers' gender and NRT dose. The purpose of this study was to determine the dose-related effects of transdermal nicotine (TN) on tobacco abstinence symptoms in 75 men and 53 women who regularly smoked cigarettes but who had abstained from smoking for at least 8-12 hr. Participants completed 4 double-blind, randomized 6.5-hr laboratory sessions that differed by TN dose (0, 7, 21, or 42 mg). Each session included blood sampling for plasma nicotine level, measurement of heart rate, participants' ratings of tobacco abstinence symptoms and effects of nicotine, and psychomotor performance. Increases in plasma nicotine level were related to TN dose and were independent of gender. TN-induced abstinence symptom suppression was dose-related for items assessing craving and urge to smoke and largely was independent of gender. TN increased heart rate and ratings of aversive side effects (e.g., nausea, lightheadedness) in a dose-related manner, and women were more sensitive at higher doses. Results from this laboratory study support the continued use of TN as a pharmacotherapy. Higher doses may ameliorate some abstinence symptoms, although the side effect profile, at least in the short term, may limit effectiveness, especially for women." @default.
- W1974576586 created "2016-06-24" @default.
- W1974576586 creator A5001485089 @default.
- W1974576586 creator A5026282031 @default.
- W1974576586 creator A5064551545 @default.
- W1974576586 creator A5070995614 @default.
- W1974576586 creator A5071397479 @default.
- W1974576586 date "2006-01-01" @default.
- W1974576586 modified "2023-10-03" @default.
- W1974576586 title "Transdermal nicotine-induced tobacco abstinence symptom suppression: Nicotine dose and smokers' gender." @default.
- W1974576586 cites W1869016054 @default.
- W1974576586 cites W1871936237 @default.
- W1974576586 cites W1894634576 @default.
- W1974576586 cites W1966941813 @default.
- W1974576586 cites W1967206044 @default.
- W1974576586 cites W1967737552 @default.
- W1974576586 cites W1968088507 @default.
- W1974576586 cites W1970495453 @default.
- W1974576586 cites W1970896977 @default.
- W1974576586 cites W1973267086 @default.
- W1974576586 cites W1974809472 @default.
- W1974576586 cites W1978603645 @default.
- W1974576586 cites W1979070739 @default.
- W1974576586 cites W1980782104 @default.
- W1974576586 cites W1991000019 @default.
- W1974576586 cites W1992797247 @default.
- W1974576586 cites W1994433788 @default.
- W1974576586 cites W1999323355 @default.
- W1974576586 cites W1999621920 @default.
- W1974576586 cites W2000136688 @default.
- W1974576586 cites W2002518023 @default.
- W1974576586 cites W2004114828 @default.
- W1974576586 cites W2004187672 @default.
- W1974576586 cites W2008032124 @default.
- W1974576586 cites W2010479382 @default.
- W1974576586 cites W2017221160 @default.
- W1974576586 cites W2018354187 @default.
- W1974576586 cites W2020799110 @default.
- W1974576586 cites W2022174236 @default.
- W1974576586 cites W2023924860 @default.
- W1974576586 cites W2024108119 @default.
- W1974576586 cites W2026479980 @default.
- W1974576586 cites W2035159684 @default.
- W1974576586 cites W2036716159 @default.
- W1974576586 cites W2037634917 @default.
- W1974576586 cites W2037934911 @default.
- W1974576586 cites W2039448408 @default.
- W1974576586 cites W2039460330 @default.
- W1974576586 cites W2039461290 @default.
- W1974576586 cites W2041639711 @default.
- W1974576586 cites W2045139779 @default.
- W1974576586 cites W2046936720 @default.
- W1974576586 cites W2049447904 @default.
- W1974576586 cites W2050674567 @default.
- W1974576586 cites W2053764128 @default.
- W1974576586 cites W2054553551 @default.
- W1974576586 cites W2057064210 @default.
- W1974576586 cites W2059083245 @default.
- W1974576586 cites W2059438277 @default.
- W1974576586 cites W2061984819 @default.
- W1974576586 cites W2063539450 @default.
- W1974576586 cites W2067802023 @default.
- W1974576586 cites W2068160854 @default.
- W1974576586 cites W2076801952 @default.
- W1974576586 cites W2081691615 @default.
- W1974576586 cites W2082503726 @default.
- W1974576586 cites W2083325514 @default.
- W1974576586 cites W2084118978 @default.
- W1974576586 cites W2084170463 @default.
- W1974576586 cites W2085618103 @default.
- W1974576586 cites W2090816637 @default.
- W1974576586 cites W2090817271 @default.
- W1974576586 cites W2090897789 @default.
- W1974576586 cites W2090989559 @default.
- W1974576586 cites W2091769432 @default.
- W1974576586 cites W2092363007 @default.
- W1974576586 cites W2094369001 @default.
- W1974576586 cites W2098475441 @default.
- W1974576586 cites W2110569081 @default.
- W1974576586 cites W2113369309 @default.
- W1974576586 cites W2118061336 @default.
- W1974576586 cites W2122435775 @default.
- W1974576586 cites W2126153666 @default.
- W1974576586 cites W2126259580 @default.
- W1974576586 cites W2134961996 @default.
- W1974576586 cites W2135151757 @default.
- W1974576586 cites W2136928880 @default.
- W1974576586 cites W2144622867 @default.
- W1974576586 cites W2153086618 @default.
- W1974576586 cites W2154538510 @default.
- W1974576586 cites W2157800353 @default.
- W1974576586 cites W2160972307 @default.
- W1974576586 cites W2163231665 @default.
- W1974576586 cites W2166752399 @default.
- W1974576586 cites W2224204666 @default.
- W1974576586 cites W2297323459 @default.
- W1974576586 cites W2315418290 @default.
- W1974576586 cites W2323458283 @default.