Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974584611> ?p ?o ?g. }
- W1974584611 endingPage "250" @default.
- W1974584611 startingPage "237" @default.
- W1974584611 abstract "The nematode Caenorhabditis elegans has become an important model for the study of innate immunity. Its immune system is based on several signaling cascades, including a Toll-like receptor, three mitogen-activated protein kinases (MAPK), one transforming growth factor-beta (TGF-beta), the insulin-like receptor (ILR), and the programmed cell death (PCD) pathway. Furthermore, it also involves C-type lectin domain- (CTLD) containing proteins as well as several classes of antimicrobial effectors such as lysozymes. Almost all components of the nematode immune system have homologs in other organisms, including humans, and are therefore likely of ancient evolutionary origin. At the same time, most of them are part of a general stress response, suggesting that they only provide unspecific defense. In the current article, we re-evaluate this suggestion and explore the level of specificity in C. elegans innate immunity, i.e. the nematode's ability to mount a distinct defense response towards different pathogens. We draw particular attention to the CTLD proteins, which are abundant in the nematode genome (278 genes) and many of which show a pathogen-specific response during infection. Specificity may also be achieved through the differential activation of antimicrobial genes, distinct functions of the immunity signaling cascades as well as signal integration across pathways. Taken together, our evaluation reveals high potential for immune specificity in C. elegans that may enhance the nematode's ability to fight off pathogens." @default.
- W1974584611 created "2016-06-24" @default.
- W1974584611 creator A5020027850 @default.
- W1974584611 creator A5046169109 @default.
- W1974584611 creator A5072841736 @default.
- W1974584611 creator A5079328759 @default.
- W1974584611 date "2008-05-01" @default.
- W1974584611 modified "2023-10-16" @default.
- W1974584611 title "Specificity of the innate immune system and diversity of C-type lectin domain (CTLD) proteins in the nematode Caenorhabditis elegans" @default.
- W1974584611 cites W1540415144 @default.
- W1974584611 cites W1654353550 @default.
- W1974584611 cites W1737667067 @default.
- W1974584611 cites W1913192897 @default.
- W1974584611 cites W1927962452 @default.
- W1974584611 cites W1965778925 @default.
- W1974584611 cites W1967434989 @default.
- W1974584611 cites W1970346847 @default.
- W1974584611 cites W1976298790 @default.
- W1974584611 cites W1976611543 @default.
- W1974584611 cites W1980515384 @default.
- W1974584611 cites W1981496396 @default.
- W1974584611 cites W1983772284 @default.
- W1974584611 cites W1985905314 @default.
- W1974584611 cites W1988376786 @default.
- W1974584611 cites W1991407027 @default.
- W1974584611 cites W1994352982 @default.
- W1974584611 cites W1996628922 @default.
- W1974584611 cites W1998684629 @default.
- W1974584611 cites W1999972142 @default.
- W1974584611 cites W2000994574 @default.
- W1974584611 cites W2001277616 @default.
- W1974584611 cites W2005222994 @default.
- W1974584611 cites W2008677145 @default.
- W1974584611 cites W2010980655 @default.
- W1974584611 cites W2013977400 @default.
- W1974584611 cites W2016856567 @default.
- W1974584611 cites W2017821695 @default.
- W1974584611 cites W2018359498 @default.
- W1974584611 cites W2020538870 @default.
- W1974584611 cites W2021477184 @default.
- W1974584611 cites W2022466704 @default.
- W1974584611 cites W2026086705 @default.
- W1974584611 cites W2027798995 @default.
- W1974584611 cites W2029601467 @default.
- W1974584611 cites W2032583854 @default.
- W1974584611 cites W2034790718 @default.
- W1974584611 cites W2036931975 @default.
- W1974584611 cites W2040868904 @default.
- W1974584611 cites W2047290093 @default.
- W1974584611 cites W2047877008 @default.
- W1974584611 cites W2052004299 @default.
- W1974584611 cites W2052471206 @default.
- W1974584611 cites W2053095874 @default.
- W1974584611 cites W2055800251 @default.
- W1974584611 cites W2059672533 @default.
- W1974584611 cites W2061676312 @default.
- W1974584611 cites W2062946341 @default.
- W1974584611 cites W2064144155 @default.
- W1974584611 cites W2065465505 @default.
- W1974584611 cites W2066753890 @default.
- W1974584611 cites W2067920944 @default.
- W1974584611 cites W2068879771 @default.
- W1974584611 cites W2073401690 @default.
- W1974584611 cites W2074565292 @default.
- W1974584611 cites W2076332010 @default.
- W1974584611 cites W2082213186 @default.
- W1974584611 cites W2085030443 @default.
- W1974584611 cites W2085034589 @default.
- W1974584611 cites W2086515125 @default.
- W1974584611 cites W2088191325 @default.
- W1974584611 cites W2095957977 @default.
- W1974584611 cites W2096653826 @default.
- W1974584611 cites W2097065022 @default.
- W1974584611 cites W2098350013 @default.
- W1974584611 cites W2099977976 @default.
- W1974584611 cites W2100925647 @default.
- W1974584611 cites W2101109925 @default.
- W1974584611 cites W2101455204 @default.
- W1974584611 cites W2102549002 @default.
- W1974584611 cites W2102676182 @default.
- W1974584611 cites W2104818214 @default.
- W1974584611 cites W2105928896 @default.
- W1974584611 cites W2106362229 @default.
- W1974584611 cites W2108565140 @default.
- W1974584611 cites W2111844766 @default.
- W1974584611 cites W2111877641 @default.
- W1974584611 cites W2112132467 @default.
- W1974584611 cites W2112809089 @default.
- W1974584611 cites W2112859601 @default.
- W1974584611 cites W2114333621 @default.
- W1974584611 cites W2114428171 @default.
- W1974584611 cites W2115003422 @default.
- W1974584611 cites W2115227037 @default.
- W1974584611 cites W2115286984 @default.
- W1974584611 cites W2115948988 @default.
- W1974584611 cites W2118266965 @default.
- W1974584611 cites W2120095412 @default.
- W1974584611 cites W2120990306 @default.