Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974612912> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1974612912 endingPage "1117" @default.
- W1974612912 startingPage "1109" @default.
- W1974612912 abstract "The aim of our study was to compare pharmacokinetic parameters of a highly bound protein drug, irbesartan, obtained from microdialysis data (MD) of arterial blood and conventional blood samples (BS). A new vascular shunt microdialysis probe was inserted into the carotid artery and one femoral vein was cannulated for i.v. administration of irbesartan. Microdialysis samples were collected every 15 min. Blood samples were taken every 15 min. Levels of drug were measured by HPLC. Pharmacokinetic parameters were estimated using topfit program. Corrected MD were compared with BS taken at same time to determine protein binding. The irbesartan protein binding did not change during the experiment. The estimated Ke from MD and BS were similar (MD: 1.8±0.3 h−1, n=5; BS: 1.7±0.2 h−1, n=5). After protein binding correction for the MD, the estimated values of volume of distribution (Vd) (MD: 1.2±0.4 l, n=5; BS: 1.1±0.4 l, n=5), clearance (Cl) (MD: 32.3±7.3 ml min−1, n=5; BS: 30.7±8.2 ml min−1, n=5) and AUC (MD: 7.7±3.2 μg ml−1 h, n=5; BS: 8.8±3.4 μg ml−1 h, n=5) were similar between MD and BS. In conclusion, these results show that our new probe inserted in the carotid artery provides accurate MD to estimate pharmacokinetic parameters of a highly bound protein drug like irbesartan. On the other hand, MD were also useful to the in vivo study of drug protein binding and saturation in protein binding." @default.
- W1974612912 created "2016-06-24" @default.
- W1974612912 creator A5001379512 @default.
- W1974612912 creator A5045403820 @default.
- W1974612912 creator A5063477355 @default.
- W1974612912 date "2003-04-01" @default.
- W1974612912 modified "2023-09-23" @default.
- W1974612912 title "Validation of a new intraarterial microdialysis shunt probe for the estimation of pharmacokinetic parameters" @default.
- W1974612912 cites W100270587 @default.
- W1974612912 cites W1530950041 @default.
- W1974612912 cites W1800057928 @default.
- W1974612912 cites W1967305865 @default.
- W1974612912 cites W1992773679 @default.
- W1974612912 cites W1996632083 @default.
- W1974612912 cites W2005660265 @default.
- W1974612912 cites W2012308910 @default.
- W1974612912 cites W2020220055 @default.
- W1974612912 cites W2024756313 @default.
- W1974612912 cites W2036739303 @default.
- W1974612912 cites W2057403644 @default.
- W1974612912 cites W2061393458 @default.
- W1974612912 cites W2064559248 @default.
- W1974612912 cites W2078656990 @default.
- W1974612912 cites W2126968506 @default.
- W1974612912 cites W2144499458 @default.
- W1974612912 cites W225072935 @default.
- W1974612912 cites W2266838684 @default.
- W1974612912 cites W38215213 @default.
- W1974612912 doi "https://doi.org/10.1016/s0731-7085(02)00652-0" @default.
- W1974612912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12667927" @default.
- W1974612912 hasPublicationYear "2003" @default.
- W1974612912 type Work @default.
- W1974612912 sameAs 1974612912 @default.
- W1974612912 citedByCount "20" @default.
- W1974612912 countsByYear W19746129122016 @default.
- W1974612912 countsByYear W19746129122017 @default.
- W1974612912 crossrefType "journal-article" @default.
- W1974612912 hasAuthorship W1974612912A5001379512 @default.
- W1974612912 hasAuthorship W1974612912A5045403820 @default.
- W1974612912 hasAuthorship W1974612912A5063477355 @default.
- W1974612912 hasConcept C112705442 @default.
- W1974612912 hasConcept C126322002 @default.
- W1974612912 hasConcept C139254425 @default.
- W1974612912 hasConcept C154020017 @default.
- W1974612912 hasConcept C185592680 @default.
- W1974612912 hasConcept C2780259554 @default.
- W1974612912 hasConcept C28406088 @default.
- W1974612912 hasConcept C43617362 @default.
- W1974612912 hasConcept C50156730 @default.
- W1974612912 hasConcept C55493867 @default.
- W1974612912 hasConcept C71924100 @default.
- W1974612912 hasConcept C84393581 @default.
- W1974612912 hasConcept C98274493 @default.
- W1974612912 hasConceptScore W1974612912C112705442 @default.
- W1974612912 hasConceptScore W1974612912C126322002 @default.
- W1974612912 hasConceptScore W1974612912C139254425 @default.
- W1974612912 hasConceptScore W1974612912C154020017 @default.
- W1974612912 hasConceptScore W1974612912C185592680 @default.
- W1974612912 hasConceptScore W1974612912C2780259554 @default.
- W1974612912 hasConceptScore W1974612912C28406088 @default.
- W1974612912 hasConceptScore W1974612912C43617362 @default.
- W1974612912 hasConceptScore W1974612912C50156730 @default.
- W1974612912 hasConceptScore W1974612912C55493867 @default.
- W1974612912 hasConceptScore W1974612912C71924100 @default.
- W1974612912 hasConceptScore W1974612912C84393581 @default.
- W1974612912 hasConceptScore W1974612912C98274493 @default.
- W1974612912 hasIssue "6" @default.
- W1974612912 hasLocation W19746129121 @default.
- W1974612912 hasLocation W19746129122 @default.
- W1974612912 hasOpenAccess W1974612912 @default.
- W1974612912 hasPrimaryLocation W19746129121 @default.
- W1974612912 hasRelatedWork W1996305828 @default.
- W1974612912 hasRelatedWork W1998531393 @default.
- W1974612912 hasRelatedWork W2011809647 @default.
- W1974612912 hasRelatedWork W2014165224 @default.
- W1974612912 hasRelatedWork W2047409028 @default.
- W1974612912 hasRelatedWork W2102652138 @default.
- W1974612912 hasRelatedWork W2264246004 @default.
- W1974612912 hasRelatedWork W2351251703 @default.
- W1974612912 hasRelatedWork W2463077557 @default.
- W1974612912 hasRelatedWork W2783095880 @default.
- W1974612912 hasVolume "31" @default.
- W1974612912 isParatext "false" @default.
- W1974612912 isRetracted "false" @default.
- W1974612912 magId "1974612912" @default.
- W1974612912 workType "article" @default.