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- W1974617197 abstract "Abstract The effect of ouabain and digitoxin upon reserpine-induced hypothermia, ptosis, and catalepsy was investigated in the mouse. Ouabain and, to a greater extent digitoxin, when given at a dose of 0.5 mg/kg ip, produced a marked potentiation of the depressant effects associated with reserpine (2.5 mg/kg ip), although at this dosage they were completely devoid of any central depressant activity when given alone. Additional experiments performed to investigate the influence of reserpine upon the myocardial toxicity of the two glycosides revealed that, in the pithed guinea pig, 24 hr pretreatment with a single dose of reserpine (2.5 mg/kg ip) protected the heart against the toxic effects of both ouabain and digitoxin. It was concluded that cardiac glycoside-reserpine interactions can occur separately within both the heart and the central nervous system. In addition, whereas at least one component of the ability of reserpine to protect against the toxic effects of the cardiac glycosides may be mediated indirectly through central mechanisms, a direct interaction within the heart itself is also involved. The relative importance of each site of action would be expected to depend upon the sensitivity of the species involved." @default.
- W1974617197 created "2016-06-24" @default.
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- W1974617197 date "1975-07-01" @default.
- W1974617197 modified "2023-09-27" @default.
- W1974617197 title "Some observations on the interaction between cardiac glycosides and reserpine in the heart and central nervous system" @default.
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- W1974617197 doi "https://doi.org/10.1016/0041-008x(75)90247-1" @default.
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