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- W1974618811 abstract "The cannabinoid receptor subtype 1 gene CNR1 is not only associated with phenotypes such as cognitive performance, addiction and anxiety, but is also known to be crucially involved in responses to acute and chronic psychological and cellular stress conditions. Functional analysis of the 5' untranslated regions of the five known mRNA variants of the human CNR1 gene revealed that two of these variants contain upstream open reading frames that are able to modulate gene expression both under baseline condition and conditions of cellular stress including hypoxia, glucose restriction and hyperthermia. The upstream open reading frames might provide a mechanism that enables the cannabinoid 1 receptor to escape the general repression of protein synthesis that is typical for conditions of cellular stress." @default.
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- W1974618811 date "2015-01-01" @default.
- W1974618811 modified "2023-09-25" @default.
- W1974618811 title "Upstream open reading frames regulate cannabinoid receptor 1 expression under baseline conditions and during cellular stress" @default.
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- W1974618811 doi "https://doi.org/10.1016/j.mce.2014.09.019" @default.
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