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- W1974657875 abstract "Bcr-AblおよびKITチロシンキナーゼ阻害薬imatinibの臨床的な成功により，多くの制がん薬の創薬研究者は『Oncogene-addiction仮説』を念頭に，第二のimatinibの研究開発に取り組んでいる．Fms-Like Tyrosine Kinase 3（FLT3）はclass III receptor tyrosine kinase familyに属し，急性骨髄性白血病（AML）で最も高頻度に活性化変異が認められる．中でもFLT3-ITD変異はAML患者の約30%に見られ，同変異を有する患者ではその生命予後が不良であることから，21世紀に入ると同時に，FLT3阻害薬開発競争が激化した．既に第一世代FLT3阻害薬でのProof-of-concept（POC）が達成されると共に，第二世代の阻害薬開発も活発となり，第一世代のFLT3阻害薬2剤は化学療法剤との併用でのPhase III試験に進んでいる．" @default.
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- W1974657875 date "2008-01-01" @default.
- W1974657875 modified "2023-09-27" @default.
- W1974657875 title "FLT3 tyrosine kinase inhibitors: current status and future perspectives for their development" @default.
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- W1974657875 doi "https://doi.org/10.1254/fpj.132.217" @default.
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