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- W1974661178 abstract "Transposable elements (TEs) are abundant in the genomes of eukaryotes, making up >40% of the nuclear DNA of humans (1). Many TEs appear to be simply selfish DNA “whose primary and often only function is self-preservation” (2). Of course, selfish behavior has effects on bystanders, and TEs can have a number of effects on the rest of the genome. TEs can affect gene expression by inserting within a gene and disrupting its structure, or by directing transcription of a nearby gene. TEs also can affect splicing and transcription termination, thereby altering the protein product of a gene. TEs can insert at multiple sites in the genome, allowing recombination between otherwise nonhomologous regions, resulting in large-scale rearrangements of chromosomes. In fact, many of the best-known TEs were initially identified because they mutated a gene under study. TEs can even have incidental benefits for the host, and there is one example of TEs devoted entirely to the benefit of the genome in which they reside, the Drosophila telomeric transposons, HeT-A and TART. In this issue of PNAS, Arkhipova and Morrison (3) report two very interesting TEs from Giardia lamblia that may also have evolved to benefit their host. This study adds another piece to the emerging picture of what happens at chromosome ends." @default.
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- W1974661178 date "2001-12-04" @default.
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- W1974661178 title "Another protozoan contributes to understanding telomeres and transposable elements" @default.
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- W1974661178 doi "https://doi.org/10.1073/pnas.261567398" @default.
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