FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974666951> ?p ?o ?g. }

• W1974666951 endingPage "755" @default.
• W1974666951 startingPage "742" @default.
• W1974666951 abstract "While insulin-like growth factor-I (IGF-I) supports neuronal and glial differentiation in the CNS, it is largely unknown whether IGF-I also influences neuronal migration and positioning. We show here that the pattern of olfactory bulb (OB) layering is altered in Igf-I −/− mice. In these animals, Tbr1+-glutamatergic neurons are misplaced in the mitral cell layer (ML) and the external plexiform layer (EPL). In addition, there are fewer interneurons in the glomerular layer and the EPL of the Igf-I −/− mice, and fewer newborn neurons are incorporated into the OB from the forebrain subventricular zone (SVZ). Indeed, neuroblasts accumulate in the postnatal/adult SVZ of Igf-I −/− mice. Significantly, the positioning of Tbr1+-cells in a primitive ML is stimulated by IGF-I in cultured embryonic OB slices, an effect that is partially repressed by the phosphoinositide 3-kinase (PI3K) inhibitor. In OB cell cultures, IGF-I increases the phosphorylation of disabled1 (P-Dab1), an adaptor protein that is a target of Src family kinases (SFK) in the reelin signalling pathway, whereas reduced P-Dab1 levels were found in Igf-I −/− mice. Neuroblast migration from the rostral migratory stream (RMS) explants of postnatal Igf-I −/− was similar to that from Igf-I +/+ explants. However, cell migration was significantly enhanced by IGF-I added to the explants, an effect that was repressed by PI3K and SFK inhibitors. These findings suggest that IGF-I promotes neuronal positioning in the OB and support a role for IGF-I in stimulating neuroblast exit from the SVZ into the RMS, thereby promoting the incorporation of newly formed neurons into the OB." @default.
• W1974666951 created "2016-06-24" @default.
• W1974666951 creator A5016966812 @default.
• W1974666951 creator A5035895809 @default.
• W1974666951 creator A5056796008 @default.
• W1974666951 creator A5060711695 @default.
• W1974666951 creator A5072688652 @default.
• W1974666951 creator A5089168647 @default.
• W1974666951 date "2009-09-01" @default.
• W1974666951 modified "2023-10-17" @default.
• W1974666951 title "IGF-I promotes neuronal migration and positioning in the olfactory bulb and the exit of neuroblasts from the subventricular zone" @default.
• W1974666951 cites W1667992367 @default.
• W1974666951 cites W1941919415 @default.
• W1974666951 cites W1963864339 @default.
• W1974666951 cites W1990044878 @default.
• W1974666951 cites W1990500865 @default.
• W1974666951 cites W1993018580 @default.
• W1974666951 cites W1993544825 @default.
• W1974666951 cites W1993710236 @default.
• W1974666951 cites W1998286599 @default.
• W1974666951 cites W2004289124 @default.
• W1974666951 cites W2005408301 @default.
• W1974666951 cites W2007242343 @default.
• W1974666951 cites W2007872544 @default.
• W1974666951 cites W2016441749 @default.
• W1974666951 cites W2024977477 @default.
• W1974666951 cites W2025557657 @default.
• W1974666951 cites W2027260046 @default.
• W1974666951 cites W2030997373 @default.
• W1974666951 cites W2039895922 @default.
• W1974666951 cites W2040407429 @default.
• W1974666951 cites W2051730106 @default.
• W1974666951 cites W2052065200 @default.
• W1974666951 cites W2054900664 @default.
• W1974666951 cites W2059702779 @default.
• W1974666951 cites W2062087581 @default.
• W1974666951 cites W2064502520 @default.
• W1974666951 cites W2066599840 @default.
• W1974666951 cites W2068170814 @default.
• W1974666951 cites W2070651871 @default.
• W1974666951 cites W2071850720 @default.
• W1974666951 cites W2074064220 @default.
• W1974666951 cites W2087641892 @default.
• W1974666951 cites W2088330078 @default.
• W1974666951 cites W2089828884 @default.
• W1974666951 cites W2093322337 @default.
• W1974666951 cites W2095783168 @default.
• W1974666951 cites W2099013296 @default.
• W1974666951 cites W2109416699 @default.
• W1974666951 cites W2111089620 @default.
• W1974666951 cites W2113873325 @default.
• W1974666951 cites W2118180039 @default.
• W1974666951 cites W2129451594 @default.
• W1974666951 cites W2145120379 @default.
• W1974666951 cites W2146548883 @default.
• W1974666951 cites W2148066913 @default.
• W1974666951 cites W2165867905 @default.
• W1974666951 cites W4295274060 @default.
• W1974666951 doi "https://doi.org/10.1111/j.1460-9568.2009.06870.x" @default.
• W1974666951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19712103" @default.
• W1974666951 hasPublicationYear "2009" @default.
• W1974666951 type Work @default.
• W1974666951 sameAs 1974666951 @default.
• W1974666951 citedByCount "118" @default.
• W1974666951 countsByYear W19746669512012 @default.
• W1974666951 countsByYear W19746669512013 @default.
• W1974666951 countsByYear W19746669512014 @default.
• W1974666951 countsByYear W19746669512015 @default.
• W1974666951 countsByYear W19746669512016 @default.
• W1974666951 countsByYear W19746669512017 @default.
• W1974666951 countsByYear W19746669512018 @default.
• W1974666951 countsByYear W19746669512019 @default.
• W1974666951 countsByYear W19746669512020 @default.
• W1974666951 countsByYear W19746669512021 @default.
• W1974666951 countsByYear W19746669512022 @default.
• W1974666951 countsByYear W19746669512023 @default.
• W1974666951 crossrefType "journal-article" @default.
• W1974666951 hasAuthorship W1974666951A5016966812 @default.
• W1974666951 hasAuthorship W1974666951A5035895809 @default.
• W1974666951 hasAuthorship W1974666951A5056796008 @default.
• W1974666951 hasAuthorship W1974666951A5060711695 @default.
• W1974666951 hasAuthorship W1974666951A5072688652 @default.
• W1974666951 hasAuthorship W1974666951A5089168647 @default.
• W1974666951 hasBestOaLocation W19746669512 @default.
• W1974666951 hasConcept C126322002 @default.
• W1974666951 hasConcept C134018914 @default.
• W1974666951 hasConcept C136834591 @default.
• W1974666951 hasConcept C169760540 @default.
• W1974666951 hasConcept C189165786 @default.
• W1974666951 hasConcept C202474031 @default.
• W1974666951 hasConcept C2777542384 @default.
• W1974666951 hasConcept C2778063154 @default.
• W1974666951 hasConcept C2779715522 @default.
• W1974666951 hasConcept C2780496858 @default.
• W1974666951 hasConcept C28328180 @default.
• W1974666951 hasConcept C39961270 @default.
• W1974666951 hasConcept C4746552 @default.
• W1974666951 hasConcept C529278444 @default.

• next