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• W1974673184 abstract "We introduce a model for describing the dynamics of large numbers of interacting cells. The fundamental dynamical variables in the model are subcellular elements, which interact with each other through phenomenological intra- and intercellular potentials. Advantages of the model include i) adaptive cell-shape dynamics, ii) flexible accommodation of additional intracellular biology, and iii) the absence of an underlying grid. We present here a detailed description of the model, and use successive mean-field approximations to connect it to more coarse-grained approaches, such as discrete cell-based algorithms and coupled partial differential equations. We also discuss efficient algorithms for encoding the model, and give an example of a simulation of an epithelial sheet. Given the biological flexibility of the model, we propose that it can be used effectively for modeling a range of multicellular processes, such as tumor dynamics and embryogenesis." @default.
• W1974673184 created "2016-06-24" @default.
• W1974673184 creator A5049125342 @default.
• W1974673184 date "2005-01-01" @default.
• W1974673184 modified "2023-10-03" @default.
• W1974673184 title "Modeling Multicellular Systems Using Subcellular Elements" @default.
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• W1974673184 doi "https://doi.org/10.3934/mbe.2005.2.613" @default.
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