Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974681242> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1974681242 endingPage "107" @default.
- W1974681242 startingPage "97" @default.
- W1974681242 abstract "Microballoons (MB) possessing a spherical cavity enclosed within a hard polymer shell have been developed as a dosage form characterized by excellent buoyancy in the stomach. MB were prepared by the emulsion solvent diffusion method using enteric acrylic polymers dissolved in a mixture of dichloromethane and ethanol. Riboflavin-containing MB were administered orally to each of three healthy volunteers. The pharmacokinetics of riboflavin was investigated by analysis of the urinary excretion. Prolongation of the urinary excretion of riboflavin could be obtained by ingestion of water as well as “fed” conditions. This phenomenon was attributable to the buoyancy properties of MB in the stomach and an increase in the gastric residence time (GRT). The excretion half-life time (t1/2) following administration of MB (particle size: 500–1000 μm) exhibiting high buoyancy was longer than that of MB (particle size: <500 μm) displaying low buoyancy. Therefore, the intragastric floating properties of MB are potentially beneficial as far as a sustained pharmacological action is concerned. MB prepared by mixing it with hydroxypropylmethylcellulose (HPMC) in different ratio, results in improved riboflavin-release properties. These MB were evaluated in vivo by analysis of the urinary excretion of riboflavin. As a result, strong correlations were observed between the buoyancy and excretion half-life (t1/2) and between the riboflavin release from the MB and total urinary excretion." @default.
- W1974681242 created "2016-06-24" @default.
- W1974681242 creator A5006318277 @default.
- W1974681242 creator A5012549810 @default.
- W1974681242 creator A5043422428 @default.
- W1974681242 creator A5061634903 @default.
- W1974681242 date "2004-05-01" @default.
- W1974681242 modified "2023-09-23" @default.
- W1974681242 title "In vitro and in vivo evaluation of riboflavin-containing microballoons for a floating controlled drug delivery system in healthy humans" @default.
- W1974681242 cites W1588208392 @default.
- W1974681242 cites W1963586714 @default.
- W1974681242 cites W1994834911 @default.
- W1974681242 cites W2032502698 @default.
- W1974681242 cites W2060712903 @default.
- W1974681242 cites W2070816484 @default.
- W1974681242 cites W2085477241 @default.
- W1974681242 cites W2085806166 @default.
- W1974681242 cites W2088408818 @default.
- W1974681242 cites W2100681906 @default.
- W1974681242 cites W2101303087 @default.
- W1974681242 cites W2135881879 @default.
- W1974681242 cites W238308256 @default.
- W1974681242 doi "https://doi.org/10.1016/j.ijpharm.2004.01.036" @default.
- W1974681242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15081141" @default.
- W1974681242 hasPublicationYear "2004" @default.
- W1974681242 type Work @default.
- W1974681242 sameAs 1974681242 @default.
- W1974681242 citedByCount "96" @default.
- W1974681242 countsByYear W19746812422012 @default.
- W1974681242 countsByYear W19746812422013 @default.
- W1974681242 countsByYear W19746812422014 @default.
- W1974681242 countsByYear W19746812422015 @default.
- W1974681242 countsByYear W19746812422016 @default.
- W1974681242 countsByYear W19746812422017 @default.
- W1974681242 countsByYear W19746812422018 @default.
- W1974681242 countsByYear W19746812422019 @default.
- W1974681242 countsByYear W19746812422020 @default.
- W1974681242 countsByYear W19746812422021 @default.
- W1974681242 countsByYear W19746812422022 @default.
- W1974681242 countsByYear W19746812422023 @default.
- W1974681242 crossrefType "journal-article" @default.
- W1974681242 hasAuthorship W1974681242A5006318277 @default.
- W1974681242 hasAuthorship W1974681242A5012549810 @default.
- W1974681242 hasAuthorship W1974681242A5043422428 @default.
- W1974681242 hasAuthorship W1974681242A5061634903 @default.
- W1974681242 hasConcept C10146269 @default.
- W1974681242 hasConcept C112705442 @default.
- W1974681242 hasConcept C150903083 @default.
- W1974681242 hasConcept C185592680 @default.
- W1974681242 hasConcept C207001950 @default.
- W1974681242 hasConcept C2776155809 @default.
- W1974681242 hasConcept C43617362 @default.
- W1974681242 hasConcept C55493867 @default.
- W1974681242 hasConcept C71924100 @default.
- W1974681242 hasConcept C77281830 @default.
- W1974681242 hasConcept C86803240 @default.
- W1974681242 hasConcept C98274493 @default.
- W1974681242 hasConceptScore W1974681242C10146269 @default.
- W1974681242 hasConceptScore W1974681242C112705442 @default.
- W1974681242 hasConceptScore W1974681242C150903083 @default.
- W1974681242 hasConceptScore W1974681242C185592680 @default.
- W1974681242 hasConceptScore W1974681242C207001950 @default.
- W1974681242 hasConceptScore W1974681242C2776155809 @default.
- W1974681242 hasConceptScore W1974681242C43617362 @default.
- W1974681242 hasConceptScore W1974681242C55493867 @default.
- W1974681242 hasConceptScore W1974681242C71924100 @default.
- W1974681242 hasConceptScore W1974681242C77281830 @default.
- W1974681242 hasConceptScore W1974681242C86803240 @default.
- W1974681242 hasConceptScore W1974681242C98274493 @default.
- W1974681242 hasIssue "1-2" @default.
- W1974681242 hasLocation W19746812421 @default.
- W1974681242 hasLocation W19746812422 @default.
- W1974681242 hasOpenAccess W1974681242 @default.
- W1974681242 hasPrimaryLocation W19746812421 @default.
- W1974681242 hasRelatedWork W1491964893 @default.
- W1974681242 hasRelatedWork W1906640546 @default.
- W1974681242 hasRelatedWork W1998587742 @default.
- W1974681242 hasRelatedWork W2004556784 @default.
- W1974681242 hasRelatedWork W2094219250 @default.
- W1974681242 hasRelatedWork W2379311614 @default.
- W1974681242 hasRelatedWork W2388069209 @default.
- W1974681242 hasRelatedWork W2582907174 @default.
- W1974681242 hasRelatedWork W2625601291 @default.
- W1974681242 hasRelatedWork W2753834235 @default.
- W1974681242 hasVolume "275" @default.
- W1974681242 isParatext "false" @default.
- W1974681242 isRetracted "false" @default.
- W1974681242 magId "1974681242" @default.
- W1974681242 workType "article" @default.