FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974694838> ?p ?o ?g. }

• W1974694838 endingPage "e21953" @default.
• W1974694838 startingPage "e21953" @default.
• W1974694838 abstract "[PSI+], the prion form of the yeast Sup35 protein, results from the structural conversion of Sup35 from a soluble form into an infectious amyloid form. The infectivity of prions is thought to result from chaperone-dependent fiber cleavage that breaks large prion fibers into smaller, inheritable propagons. Like the mammalian prion protein PrP, Sup35 contains an oligopeptide repeat domain. Deletion analysis indicates that the oligopeptide repeat domain is critical for [PSI+] propagation, while a distinct region of the prion domain is responsible for prion nucleation. The PrP oligopeptide repeat domain can substitute for the Sup35 oligopeptide repeat domain in supporting [PSI+] propagation, suggesting a common role for repeats in supporting prion maintenance. However, randomizing the order of the amino acids in the Sup35 prion domain does not block prion formation or propagation, suggesting that amino acid composition is the primary determinant of Sup35's prion propensity. Thus, it is unclear what role the oligopeptide repeats play in [PSI+] propagation: the repeats could simply act as a non-specific spacer separating the prion nucleation domain from the rest of the protein; the repeats could contain specific compositional elements that promote prion propagation; or the repeats, while not essential for prion propagation, might explain some unique features of [PSI+]. Here, we test these three hypotheses and show that the ability of the Sup35 and PrP repeats to support [PSI+] propagation stems from their amino acid composition, not their primary sequences. Furthermore, we demonstrate that compositional requirements for the repeat domain are distinct from those of the nucleation domain, indicating that prion nucleation and propagation are driven by distinct compositional features." @default.
• W1974694838 created "2016-06-24" @default.
• W1974694838 creator A5011780356 @default.
• W1974694838 creator A5014741290 @default.
• W1974694838 creator A5060089537 @default.
• W1974694838 creator A5061540805 @default.
• W1974694838 creator A5067205503 @default.
• W1974694838 date "2011-07-08" @default.
• W1974694838 modified "2023-09-25" @default.
• W1974694838 title "[PSI+] Maintenance Is Dependent on the Composition, Not Primary Sequence, of the Oligopeptide Repeat Domain" @default.
• W1974694838 cites W1521738036 @default.
• W1974694838 cites W1553457312 @default.
• W1974694838 cites W1561188835 @default.
• W1974694838 cites W1857855090 @default.
• W1974694838 cites W1872122 @default.
• W1974694838 cites W1939575473 @default.
• W1974694838 cites W1963901715 @default.
• W1974694838 cites W1964661966 @default.
• W1974694838 cites W1979575360 @default.
• W1974694838 cites W1990839192 @default.
• W1974694838 cites W1993027148 @default.
• W1974694838 cites W2000204824 @default.
• W1974694838 cites W2000572271 @default.
• W1974694838 cites W2001624926 @default.
• W1974694838 cites W2006934202 @default.
• W1974694838 cites W2013112316 @default.
• W1974694838 cites W2018101403 @default.
• W1974694838 cites W2025482639 @default.
• W1974694838 cites W2036404841 @default.
• W1974694838 cites W2043129489 @default.
• W1974694838 cites W2046445620 @default.
• W1974694838 cites W2058993984 @default.
• W1974694838 cites W2066455526 @default.
• W1974694838 cites W2066946197 @default.
• W1974694838 cites W2070387353 @default.
• W1974694838 cites W2076574908 @default.
• W1974694838 cites W2084968424 @default.
• W1974694838 cites W2094307858 @default.
• W1974694838 cites W2102419674 @default.
• W1974694838 cites W2103884669 @default.
• W1974694838 cites W2112335210 @default.
• W1974694838 cites W2112650804 @default.
• W1974694838 cites W2119837637 @default.
• W1974694838 cites W2122056682 @default.
• W1974694838 cites W2123565113 @default.
• W1974694838 cites W2126000459 @default.
• W1974694838 cites W2128311557 @default.
• W1974694838 cites W2129602427 @default.
• W1974694838 cites W2130104108 @default.
• W1974694838 cites W2130451115 @default.
• W1974694838 cites W2135655710 @default.
• W1974694838 cites W2136758030 @default.
• W1974694838 cites W2137158072 @default.
• W1974694838 cites W2139418286 @default.
• W1974694838 cites W2150234014 @default.
• W1974694838 cites W2152958744 @default.
• W1974694838 cites W2157003093 @default.
• W1974694838 cites W2163463501 @default.
• W1974694838 cites W2163842045 @default.
• W1974694838 cites W2165315960 @default.
• W1974694838 cites W2284316917 @default.
• W1974694838 cites W4240065971 @default.
• W1974694838 doi "https://doi.org/10.1371/journal.pone.0021953" @default.
• W1974694838 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3132755" @default.
• W1974694838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21760933" @default.
• W1974694838 hasPublicationYear "2011" @default.
• W1974694838 type Work @default.
• W1974694838 sameAs 1974694838 @default.
• W1974694838 citedByCount "28" @default.
• W1974694838 countsByYear W19746948382012 @default.
• W1974694838 countsByYear W19746948382013 @default.
• W1974694838 countsByYear W19746948382014 @default.
• W1974694838 countsByYear W19746948382015 @default.
• W1974694838 countsByYear W19746948382016 @default.
• W1974694838 countsByYear W19746948382017 @default.
• W1974694838 countsByYear W19746948382019 @default.
• W1974694838 countsByYear W19746948382020 @default.
• W1974694838 countsByYear W19746948382021 @default.
• W1974694838 countsByYear W19746948382023 @default.
• W1974694838 crossrefType "journal-article" @default.
• W1974694838 hasAuthorship W1974694838A5011780356 @default.
• W1974694838 hasAuthorship W1974694838A5014741290 @default.
• W1974694838 hasAuthorship W1974694838A5060089537 @default.
• W1974694838 hasAuthorship W1974694838A5061540805 @default.
• W1974694838 hasAuthorship W1974694838A5067205503 @default.
• W1974694838 hasBestOaLocation W19746948381 @default.
• W1974694838 hasConcept C104317684 @default.
• W1974694838 hasConcept C118963712 @default.
• W1974694838 hasConcept C12554922 @default.
• W1974694838 hasConcept C13935069 @default.
• W1974694838 hasConcept C167625842 @default.
• W1974694838 hasConcept C185592680 @default.
• W1974694838 hasConcept C2777576037 @default.
• W1974694838 hasConcept C2779281246 @default.
• W1974694838 hasConcept C515207424 @default.
• W1974694838 hasConcept C54355233 @default.
• W1974694838 hasConcept C55493867 @default.
• W1974694838 hasConcept C86803240 @default.

• next