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- W1974704920 abstract "A prospective, randomized study was undertaken in neutropenic patients to evaluate the efficacy of prophylactic trimethoprim/sulfamethoxazole in reducing infections and to assess the effect of prophylaxis on bacterial and fungal flora. Fifty-five patients with leukemia, lymphoma, or solid tumors randomly received either one single-strength trimethoprim/sulfamethoxazole tablet twice daily or no drug for the period of expected neutropenia. Trimethoprim/ sulfamethoxazole prophylaxis did not significantly reduce the mean number of febrile days per patient, but did decrease the number of documented infections. The control group experienced 28 infections, including 11 bacteremias and seven infection-associated deaths; the group that received trimethoprim/sulfamethoxazole had seven infections, including two bacteremias and no infection-related deaths. Patients treated with trimethoprim/sulfamethoxazole had no enteric gram-negative bacillary infections compared with 12 infections in the control group. Fungal infections occurred in four control patients but only in one patient who received trimethoprim/sulfamethoxazole. Surveillance cultures revealed that trimethoprim/sulfamethoxazole prophylaxis did not lead to colonization with trimethoprim/sulfamethoxazole-resistant Enterobacteriaceae, Pseudomonas, or fungi. Colonization with filamentous fungi was common in both groups and was related to season of the year rather than prophylactic antibiotic therapy. In conclusion, trimethoprim/ sulfamethoxazole prophylaxis reduced infectious episodes in neutropenic patients without increasing the risk of fungal and trimethoprim/sulfamethoxazole-resistant gram-negative bacillary infections." @default.
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- W1974704920 date "1983-04-01" @default.
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- W1974704920 title "Trimethoprim/sulfamethoxazole prophylaxis in neutropenic patients" @default.
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- W1974704920 doi "https://doi.org/10.1016/0002-9343(83)91017-3" @default.
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