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• W1974709141 abstract "In Streptomyces coelicolor , the AbsA1–AbsA2 two‐component system regulates the expression of multiple antibiotic gene clusters. Here, we show that the response regulator encoded by the absA2 gene is a negative regulator of these antibiotic gene clusters. A genetic analysis shows that the phosphorylated form of the AbsA2 response regulator (phospho‐AbsA2), generated by the cognate AbsA1 sensor histidine kinase, is required for normal growth phase regulation of antibiotic synthesis. In the absence of phospho‐AbsA2, antibiotics are produced earlier and more abundantly. Overexpression of AbsA1 also deregulates antibiotic synthesis, apparently shifting the AbsA1 protein from a kinase‐active to a phospho‐AbsA2 phosphatase‐active form. The absA1 and absA2 genes, which are adjacent, are located in one of the antibiotic gene clusters that they regulate, the cluster for the calcium‐dependent antibiotic (CDA). The absA genes themselves are growth phase regulated, with phospho‐AbsA2 responsible for growth phase‐related positive autoregulation. We discuss the possible role and mechanism of AbsA‐mediated regulation of antibiotic synthesis in the S. coelicolor life cycle." @default.
• W1974709141 created "2016-06-24" @default.
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• W1974709141 date "2001-02-01" @default.
• W1974709141 modified "2023-10-15" @default.
• W1974709141 title "Genetic and transcriptional analysis of <i>absA</i>, an antibiotic gene cluster‐linked two‐component system that regulates multiple antibiotics in <i>Streptomyces coelicolor</i>" @default.
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• W1974709141 doi "https://doi.org/10.1046/j.1365-2958.2001.02240.x" @default.
• W1974709141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11169098" @default.
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