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- W1974720439 abstract "Abstract Objective —To determine the concentration and binding characteristics of α-adrenoceptor subtypes in smooth muscle cell membranes of equine ileum. Sample Population —Segments of longitudinal and circular smooth muscle from the ileum of 8 male and 8 female adult horses. Procedure —Distribution of α-adrenoceptor subtypes was assessed by use of radioligand binding assays incorporating [ 3 H]-prazosin and [ 3 H]-rauwolscine, highly selective α 1 - and α 2 -adrenoceptor antagonists, respectively. Characterization of adrenoceptor subtypes was performed by use of binding inhibition assays. Results —On the basis of binding affinity for specific radioligands, low- and high-affinity α 1 - and α 2 -adrenoceptors were detected. Concentration of low-affinity α 2 -adrenoceptors was significantly greater in male horses, compared with females. Competition studies confirmed the specificity of the radioligands used in the binding assays. α 1 -Adrenoceptors of both subtypes in male and female horses had a higher affinity for prazosin than phentolamine, whereas yohimbine did not compete with the radioligand for binding. For α 2 -adrenoceptors regardless of subtype, potency of inhibition elicited by each drug varied between sexes. In males, yohimbine was a more potent inhibitor than phentolamine, which was more potent than prazosin. In females, yohimbine was more potent than prazosin, which was more potent than phentolamine. Conclusions and Clinical Relevance —High- and low-affinity α 1 - and α 2 -adrenoceptors were detected in smooth muscle of equine ileum. Because α-adrenoceptor subtypes, particularly α 2 -adrenoceptors, are involved in the regulation of gastrointestinal tract function, characterization of these receptors may represent the basis for development of new therapeutic strategies for the control of gastrointestinal disturbances in horses. ( Am J Vet Res 2001;62:1370–1374)" @default.
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- W1974720439 date "2001-09-01" @default.
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- W1974720439 title "Characterization of α-adrenoceptor subtypes in smooth muscle of equine ileum" @default.
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- W1974720439 doi "https://doi.org/10.2460/ajvr.2001.62.1370" @default.
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