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- W1974734300 abstract "The pituitary gonadotropin follicle-stimulating hormone (FSH) interacts with its membrane-bound receptor to produce biologic effects. Traditional functions of FSH include follicular development estradiol production in females the regulation of Sertoli cell action spermatogenesis in males. Knockout mice for both the ligand (Fshb) the receptor (Fshr) serve as models for FSH deficiency while Fshb Fshr transgenic mice manifest FSH excess. In addition inactivating mutations of both human orthologs (FSHB FSHR) have been characterized in a small number of patients with phenotypic effects of the ligand disruption being more profound than those of its receptor. Activating human FSHR mutants have also been described in both sexes leading to a phenotype of normal testis function (male) or spontaneous ovarian hyperstimulation syndrome (females). As determined from human mouse models FSH is essential for normal puberty fertility in females particularly for ovarian follicular development beyond the antral stage. In males FSH is necessary for normal spermatogenesis but there are differences in human mouse models. The FSHB mutations in humans result in azoospermia; while FSHR mutations in humans knockouts of both the ligand the receptor in mice affect testicular function but do not result in absolute infertility. Available evidence also indicates that FSH may also be necessary for normal androgen synthesis in males females." @default.
- W1974734300 created "2016-06-24" @default.
- W1974734300 creator A5017707833 @default.
- W1974734300 creator A5026909252 @default.
- W1974734300 creator A5079103590 @default.
- W1974734300 creator A5083023939 @default.
- W1974734300 date "2013-03-01" @default.
- W1974734300 modified "2023-10-07" @default.
- W1974734300 title "The Molecular Basis of Impaired Follicle-Stimulating Hormone Action: Evidence From Human Mutations and Mouse Models" @default.
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- W1974734300 doi "https://doi.org/10.1177/1933719112461184" @default.
- W1974734300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3823505" @default.
- W1974734300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23184658" @default.
- W1974734300 hasPublicationYear "2013" @default.