Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974745837> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1974745837 endingPage "77" @default.
- W1974745837 startingPage "69" @default.
- W1974745837 abstract "The existence of the blood-brain barrier (BBB) has been recognised for quite some time, but there is still a great deal of confusion among neurobiologists and neurologists as to what it is and how it is regulated. However, there is general agreement that the BBB plays an essential role in influencing the cellular environment in the brain under normal and abnormal conditions. For example, the BBB prevents trafficking of most proteins and even small hydrophilic molecules (including ions) between blood and brain. Situations in which the normal low permeability of the BBB is altered can have serious consequences. For instance, following an ischaemic event, the barrier is disrupted, ions and proteins enter the brain at markedly higher than normal rates, and water molecules follow to maintain osmotic balance. This results in brain oedema, the extent of which is an important determinant of speed of recovery from the initial insult. The barrier is also abrogated, albeit transiently, when cells enter the brain from the blood. This happens in disorders such as multiple sclerosis, caused, presumably, by the entry of activated oligodendrocyte-reactive T-lymphocytes into the brain. Cell trafficking from blood to brain also underlies the formation of metastatic brain tumours. Clearly, then, methods of selectively decreasing BBB permeability would be useful under certain circumstances. However, there is also a great deal of interest in reversibly increasing the permeability of BBB to allow delivery of neuro-therapeutic agents (such as nerve growth factor, which is an anti-degenerative peptide growth factor that might be useful in treating Alzheimer’s disease) to the brain." @default.
- W1974745837 created "2016-06-24" @default.
- W1974745837 creator A5013632436 @default.
- W1974745837 creator A5056524310 @default.
- W1974745837 creator A5071625232 @default.
- W1974745837 date "1994-01-01" @default.
- W1974745837 modified "2023-09-24" @default.
- W1974745837 title "Tight Junctions and the Blood-Brain Barrier" @default.
- W1974745837 cites W1977940746 @default.
- W1974745837 cites W1982446641 @default.
- W1974745837 cites W1982974412 @default.
- W1974745837 cites W1983227350 @default.
- W1974745837 cites W198520409 @default.
- W1974745837 cites W2005447528 @default.
- W1974745837 cites W20218504 @default.
- W1974745837 cites W2032494769 @default.
- W1974745837 cites W2041783728 @default.
- W1974745837 cites W2067733328 @default.
- W1974745837 cites W2076634690 @default.
- W1974745837 cites W2085146964 @default.
- W1974745837 cites W2096049968 @default.
- W1974745837 cites W2101290420 @default.
- W1974745837 cites W2130516208 @default.
- W1974745837 cites W2137261534 @default.
- W1974745837 cites W2152353759 @default.
- W1974745837 cites W2155579605 @default.
- W1974745837 cites W78918733 @default.
- W1974745837 doi "https://doi.org/10.1007/978-3-662-03011-0_5" @default.
- W1974745837 hasPublicationYear "1994" @default.
- W1974745837 type Work @default.
- W1974745837 sameAs 1974745837 @default.
- W1974745837 citedByCount "0" @default.
- W1974745837 crossrefType "book-chapter" @default.
- W1974745837 hasAuthorship W1974745837A5013632436 @default.
- W1974745837 hasAuthorship W1974745837A5056524310 @default.
- W1974745837 hasAuthorship W1974745837A5071625232 @default.
- W1974745837 hasConcept C11171543 @default.
- W1974745837 hasConcept C134018914 @default.
- W1974745837 hasConcept C15744967 @default.
- W1974745837 hasConcept C169760540 @default.
- W1974745837 hasConcept C177779419 @default.
- W1974745837 hasConcept C203014093 @default.
- W1974745837 hasConcept C2777649898 @default.
- W1974745837 hasConcept C2778402981 @default.
- W1974745837 hasConcept C2780640218 @default.
- W1974745837 hasConcept C2781140086 @default.
- W1974745837 hasConcept C529278444 @default.
- W1974745837 hasConcept C71924100 @default.
- W1974745837 hasConcept C86803240 @default.
- W1974745837 hasConcept C95444343 @default.
- W1974745837 hasConceptScore W1974745837C11171543 @default.
- W1974745837 hasConceptScore W1974745837C134018914 @default.
- W1974745837 hasConceptScore W1974745837C15744967 @default.
- W1974745837 hasConceptScore W1974745837C169760540 @default.
- W1974745837 hasConceptScore W1974745837C177779419 @default.
- W1974745837 hasConceptScore W1974745837C203014093 @default.
- W1974745837 hasConceptScore W1974745837C2777649898 @default.
- W1974745837 hasConceptScore W1974745837C2778402981 @default.
- W1974745837 hasConceptScore W1974745837C2780640218 @default.
- W1974745837 hasConceptScore W1974745837C2781140086 @default.
- W1974745837 hasConceptScore W1974745837C529278444 @default.
- W1974745837 hasConceptScore W1974745837C71924100 @default.
- W1974745837 hasConceptScore W1974745837C86803240 @default.
- W1974745837 hasConceptScore W1974745837C95444343 @default.
- W1974745837 hasLocation W19747458371 @default.
- W1974745837 hasOpenAccess W1974745837 @default.
- W1974745837 hasPrimaryLocation W19747458371 @default.
- W1974745837 hasRelatedWork W1019639040 @default.
- W1974745837 hasRelatedWork W1454519016 @default.
- W1974745837 hasRelatedWork W147418909 @default.
- W1974745837 hasRelatedWork W1510202215 @default.
- W1974745837 hasRelatedWork W1523564114 @default.
- W1974745837 hasRelatedWork W1817830375 @default.
- W1974745837 hasRelatedWork W1827390534 @default.
- W1974745837 hasRelatedWork W182956977 @default.
- W1974745837 hasRelatedWork W1990946868 @default.
- W1974745837 hasRelatedWork W1996574563 @default.
- W1974745837 hasRelatedWork W2157779105 @default.
- W1974745837 hasRelatedWork W2477281255 @default.
- W1974745837 hasRelatedWork W2606541781 @default.
- W1974745837 hasRelatedWork W2789748336 @default.
- W1974745837 hasRelatedWork W3000536289 @default.
- W1974745837 hasRelatedWork W3099473825 @default.
- W1974745837 hasRelatedWork W32088353 @default.
- W1974745837 hasRelatedWork W66843061 @default.
- W1974745837 hasRelatedWork W73713724 @default.
- W1974745837 hasRelatedWork W2135874031 @default.
- W1974745837 isParatext "false" @default.
- W1974745837 isRetracted "false" @default.
- W1974745837 magId "1974745837" @default.
- W1974745837 workType "book-chapter" @default.