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• W1974745940 abstract "Six new polyketides, simplexolides A–E (1–5) and a furan ester, plakorfuran A (6), together with four known furanylidenic methyl esters (7–10) were isolated from the marine sponge Plakortis simplex. Compounds 1–5 feature a tetrahydrofuran ring opened seco-plakortone skeleton. These new structures, including relative configurations, were determined on the basis of extensive analysis of spectroscopic data. The absolute configurations of 1–6 were established by the modified Mosher’s method, and the CD exciton chirality method. However, configurations of the remote stereocenters at C-8 in compounds 1–5 were not determined. Antifungal, cytotoxicity, antileismanial, and antimalarial activities of these polyketides were evaluated." @default.
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• W1974745940 date "2012-06-01" @default.
• W1974745940 modified "2023-09-30" @default.
• W1974745940 title "Simplexolides A–E and plakorfuran A, six butyrate derived polyketides from the marine sponge Plakortis simplex" @default.
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• W1974745940 doi "https://doi.org/10.1016/j.tet.2012.04.025" @default.
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