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- W1974757842 abstract "The administration of phenobarbital (100 mg/kg) or chlorcyclizine (50 g/kg) to rats by stomach tube daily for 1 week resulted in significant increases in liver weight, microsomal protein concentration and the activity of the NADPH-dependent hepatic microsomal ethanol-oxidizing system (MEOS). Pretreatment with either of these agents, however, had no significant effect on ethanol metabolism in vitro by liver slices. Pretreatment with phenobarbital had no effect on the rate of ethanol metabolism in vivo as measured in the whole body or as estimated from the rate of decrease of blood ethanol concentration, at either 24 or 48 hr after the last dose of phenobarbital. Chronic treatment with ethanol in a high fat adequate protein liquid diet or in a high protein low fat liquid diet resulted in a significant increase in the rate of disappearance of ethanol from blood and the calculated rate of ethanol metabolism. However, no increase in MEOS occurred on a high protein, low fat diet. It is concluded that changes in MEOS bear no relationship to metabolic tolerance to ethanol or to cross-tolerance between ethanol and drugs." @default.
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- W1974757842 date "1972-08-01" @default.
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- W1974757842 title "Significance in vivo of the increase in micro-somal ethanol-oxidizing system after chronic administration of ethanol, pheno-barbital and chlorcyclizine" @default.
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- W1974757842 doi "https://doi.org/10.1016/0006-2952(72)90037-8" @default.
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