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- W1974776482 abstract "We show here a novel non-viral strategy to transduce human cells by using an EBV-based vector system. The EBV-based vectors, the plasmid vectors carrying EBV oriP (origin for plasmid replication) and EBNA (EBV nuclear antigen) 1 gene from EBV genome, were combined with 2 gene delivery systems, i.e., cationic liposome and HVJ-liposome. By both methods, EBV-based vectors could be more efficiently transfected into HeLa cells than non-EBV, conventional plasmid vectors. When human primary fibroblasts were transfected, EBV-based vectors coupled with cationic liposome but HVJ-liposome resulted in successful gene transduction, while human bone marrow cells were transduced with both HVJ-liposome- and cationic liposome-EBV vectors. These results suggest the potential applications of the EBV-based vector system for gene therapy." @default.
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- W1974776482 date "1997-09-01" @default.
- W1974776482 modified "2023-10-14" @default.
- W1974776482 title "Efficient Gene Transduction by Epstein–Barr-Virus-Based Vectors Coupled with Cationic Liposome and HVJ-Liposome" @default.
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- W1974776482 doi "https://doi.org/10.1006/bbrc.1997.7060" @default.
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