FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974778911> ?p ?o ?g. }

• W1974778911 endingPage "412" @default.
• W1974778911 startingPage "406" @default.
• W1974778911 abstract "The distribution of iodine-131 (131I) labelled antibody to carcinoembryonic antigen (CEA) has been studied in 16 patients with colorectal cancer. Levels of tumour and normal tissue radioactivity were measured by serial gamma-camera imaging and counting of blood and urine. Maximum concentrations were found in tumour 8 h after administration and varied up to 9-fold in different patients. Higher levels were found on average in tumour than in any other tissue. Liver, lung and blood were the other tissues in which antibody was concentrated relative to the rest of the body. Antibody cleared from all these tissues over 1 week. Second antibody directed against the antitumour (first) antibody was given 24 h after first antibody in order to accelerate clearance from the blood. This increased the tumour to blood ratio but had little effect on other tissues. Cumulative radiation dose to tumour and normal tissue was estimated. In patients with the most efficient localisation the tumour to body ratio was 20:1 and tumour to blood ratio 5:1. This may be sufficient for effective therapy of cancer in patients selected for efficient antibody localisation. The data may be used to estimate the effect of different therapeutic strategies. For instance, in the time after second antibody administration the average tumour to blood ratio of radiation dose was 11:1, suggesting that two phase systems in which the therapeutic modality is given after a good tumour to normal tissue ratio is obtained may be effective for the majority of patients." @default.
• W1974778911 created "2016-06-24" @default.
• W1974778911 creator A5000854265 @default.
• W1974778911 creator A5010881489 @default.
• W1974778911 creator A5020285429 @default.
• W1974778911 creator A5026768443 @default.
• W1974778911 creator A5044974788 @default.
• W1974778911 creator A5046026691 @default.
• W1974778911 creator A5052476911 @default.
• W1974778911 creator A5055711498 @default.
• W1974778911 creator A5073816879 @default.
• W1974778911 creator A5074143174 @default.
• W1974778911 date "1989-09-01" @default.
• W1974778911 modified "2023-10-10" @default.
• W1974778911 title "Antibody distribution and dosimetry in patients receiving radiolabelled antibody therapy for colorectal cancer" @default.
• W1974778911 cites W1605162359 @default.
• W1974778911 cites W165057632 @default.
• W1974778911 cites W1826412460 @default.
• W1974778911 cites W1839751882 @default.
• W1974778911 cites W1866856027 @default.
• W1974778911 cites W1945721659 @default.
• W1974778911 cites W1964560011 @default.
• W1974778911 cites W1967889416 @default.
• W1974778911 cites W1970506196 @default.
• W1974778911 cites W1983430641 @default.
• W1974778911 cites W1984893522 @default.
• W1974778911 cites W2001166376 @default.
• W1974778911 cites W2001636191 @default.
• W1974778911 cites W2002492512 @default.
• W1974778911 cites W2009525595 @default.
• W1974778911 cites W2021203247 @default.
• W1974778911 cites W2028735088 @default.
• W1974778911 cites W2041210461 @default.
• W1974778911 cites W2051330838 @default.
• W1974778911 cites W2107683656 @default.
• W1974778911 cites W2108980544 @default.
• W1974778911 cites W2131059538 @default.
• W1974778911 cites W2140308459 @default.
• W1974778911 cites W2338107399 @default.
• W1974778911 cites W2409794844 @default.
• W1974778911 cites W2431130137 @default.
• W1974778911 doi "https://doi.org/10.1038/bjc.1989.295" @default.
• W1974778911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2247181" @default.
• W1974778911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2789951" @default.
• W1974778911 hasPublicationYear "1989" @default.
• W1974778911 type Work @default.
• W1974778911 sameAs 1974778911 @default.
• W1974778911 citedByCount "63" @default.
• W1974778911 countsByYear W19747789112017 @default.
• W1974778911 countsByYear W19747789112018 @default.
• W1974778911 countsByYear W19747789112023 @default.
• W1974778911 crossrefType "journal-article" @default.
• W1974778911 hasAuthorship W1974778911A5000854265 @default.
• W1974778911 hasAuthorship W1974778911A5010881489 @default.
• W1974778911 hasAuthorship W1974778911A5020285429 @default.
• W1974778911 hasAuthorship W1974778911A5026768443 @default.
• W1974778911 hasAuthorship W1974778911A5044974788 @default.
• W1974778911 hasAuthorship W1974778911A5046026691 @default.
• W1974778911 hasAuthorship W1974778911A5052476911 @default.
• W1974778911 hasAuthorship W1974778911A5055711498 @default.
• W1974778911 hasAuthorship W1974778911A5073816879 @default.
• W1974778911 hasAuthorship W1974778911A5074143174 @default.
• W1974778911 hasBestOaLocation W19747789111 @default.
• W1974778911 hasConcept C112705442 @default.
• W1974778911 hasConcept C121608353 @default.
• W1974778911 hasConcept C126322002 @default.
• W1974778911 hasConcept C142724271 @default.
• W1974778911 hasConcept C159654299 @default.
• W1974778911 hasConcept C203014093 @default.
• W1974778911 hasConcept C2776146153 @default.
• W1974778911 hasConcept C2777387746 @default.
• W1974778911 hasConcept C526805850 @default.
• W1974778911 hasConcept C542903549 @default.
• W1974778911 hasConcept C71924100 @default.
• W1974778911 hasConceptScore W1974778911C112705442 @default.
• W1974778911 hasConceptScore W1974778911C121608353 @default.
• W1974778911 hasConceptScore W1974778911C126322002 @default.
• W1974778911 hasConceptScore W1974778911C142724271 @default.
• W1974778911 hasConceptScore W1974778911C159654299 @default.
• W1974778911 hasConceptScore W1974778911C203014093 @default.
• W1974778911 hasConceptScore W1974778911C2776146153 @default.
• W1974778911 hasConceptScore W1974778911C2777387746 @default.
• W1974778911 hasConceptScore W1974778911C526805850 @default.
• W1974778911 hasConceptScore W1974778911C542903549 @default.
• W1974778911 hasConceptScore W1974778911C71924100 @default.
• W1974778911 hasIssue "3" @default.
• W1974778911 hasLocation W19747789111 @default.
• W1974778911 hasLocation W19747789112 @default.
• W1974778911 hasLocation W19747789113 @default.
• W1974778911 hasLocation W19747789114 @default.
• W1974778911 hasOpenAccess W1974778911 @default.
• W1974778911 hasPrimaryLocation W19747789111 @default.
• W1974778911 hasRelatedWork W1517145497 @default.
• W1974778911 hasRelatedWork W1974778911 @default.
• W1974778911 hasRelatedWork W2001166376 @default.
• W1974778911 hasRelatedWork W2046743973 @default.
• W1974778911 hasRelatedWork W2056526459 @default.
• W1974778911 hasRelatedWork W2088209396 @default.

• next