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• W1974790023 endingPage "981" @default.
• W1974790023 startingPage "967" @default.
• W1974790023 abstract "Inheritance of a single copy of the gene encoding huntingtin (HD) with an expanded polyglutamine-encoding CAG repeat leads to neuronal dysfunction, neurodegeneration and the development of the symptoms of Huntington's disease (HD). We have found that the steady-state mRNA levels of two members of the phosphodiesterase (PDE) multi-gene family decrease over time in the striatum of R6 transgenic HD mice relative to age-matched wild-type littermates. Phosphodiesterase 10A (PDE10A) mRNA and protein levels decline in the striatum of R6/1 and R6/2 HD mice prior to motor symptom development. The rate of reduction in PDE10A protein correlates with the rate of decline of the message and the decrease in PDE10A mRNA and protein is more rapid in R6/2 compared with R6/1 mice. Both PDE10A protein and mRNA, therefore, decline to minimum levels prior to the onset of overt physical symptoms in both strains of transgenic mice. Moreover, protein levels of PDE10A are decreased in the caudate-putamen of grade 3 HD patients compared with age-matched neuropathologically normal controls. Striatal PDE1B mRNA levels also decline in R6/1 and R6/2 HD mice; however, the decrease in striatal PDE10A levels (>60%) was greater than that observed for PDE1B and immediately preceded the onset of motor symptoms. In contrast, PDE4A mRNA levels are relatively low in the striatum and do not differ between age-matched wild-type and transgenic HD mice. This suggests that the regulation of PDE10A and PDE1B, but not PDE4A, mRNA levels is dependent on the relative expression of or number of CAG repeats within the human HD transgene. The loss of phosphodiesterase activity may lead to dysregulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) levels in the striatum, a region of the brain that contributes to the control of movement and cognition." @default.
• W1974790023 created "2016-06-24" @default.
• W1974790023 creator A5016431105 @default.
• W1974790023 creator A5051823738 @default.
• W1974790023 creator A5088113414 @default.
• W1974790023 date "2004-01-01" @default.
• W1974790023 modified "2023-10-16" @default.
• W1974790023 title "Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington′s disease transgenic mice prior to the onset of motor symptoms" @default.
• W1974790023 cites W1499000998 @default.
• W1974790023 cites W1505831848 @default.
• W1974790023 cites W1522478928 @default.
• W1974790023 cites W1524509448 @default.
• W1974790023 cites W1631029899 @default.
• W1974790023 cites W1639255528 @default.
• W1974790023 cites W1790746766 @default.
• W1974790023 cites W1855026199 @default.
• W1974790023 cites W1926212373 @default.
• W1974790023 cites W1963552002 @default.
• W1974790023 cites W1967882515 @default.
• W1974790023 cites W1970846913 @default.
• W1974790023 cites W1975769625 @default.
• W1974790023 cites W1977733590 @default.
• W1974790023 cites W1977983193 @default.
• W1974790023 cites W1978580506 @default.
• W1974790023 cites W1978583856 @default.
• W1974790023 cites W1981771056 @default.
• W1974790023 cites W1985926670 @default.
• W1974790023 cites W1993068285 @default.
• W1974790023 cites W1993191686 @default.
• W1974790023 cites W1995489117 @default.
• W1974790023 cites W2002193130 @default.
• W1974790023 cites W2002644780 @default.
• W1974790023 cites W2004991138 @default.
• W1974790023 cites W2005819729 @default.
• W1974790023 cites W2006636408 @default.
• W1974790023 cites W2008561777 @default.
• W1974790023 cites W2010269783 @default.
• W1974790023 cites W2012442320 @default.
• W1974790023 cites W2012481532 @default.
• W1974790023 cites W2014407272 @default.
• W1974790023 cites W2020206460 @default.
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• W1974790023 cites W2025578163 @default.
• W1974790023 cites W2026437143 @default.
• W1974790023 cites W2028109077 @default.
• W1974790023 cites W2032255653 @default.
• W1974790023 cites W2033717303 @default.
• W1974790023 cites W2039909964 @default.
• W1974790023 cites W2042141510 @default.
• W1974790023 cites W2042419203 @default.
• W1974790023 cites W2044559546 @default.
• W1974790023 cites W2045750611 @default.
• W1974790023 cites W2048787249 @default.
• W1974790023 cites W2055283129 @default.
• W1974790023 cites W2057392628 @default.
• W1974790023 cites W2059040859 @default.
• W1974790023 cites W2062102056 @default.
• W1974790023 cites W2062682951 @default.
• W1974790023 cites W2067709327 @default.
• W1974790023 cites W2069850109 @default.
• W1974790023 cites W2079879584 @default.
• W1974790023 cites W2082056883 @default.
• W1974790023 cites W2086859078 @default.
• W1974790023 cites W2088379827 @default.
• W1974790023 cites W2088763860 @default.
• W1974790023 cites W2089403797 @default.
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• W1974790023 cites W2122440289 @default.
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• W1974790023 cites W2136218435 @default.
• W1974790023 cites W2140795771 @default.
• W1974790023 cites W2156621978 @default.
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• W1974790023 cites W2171439103 @default.
• W1974790023 cites W2178290039 @default.
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• W1974790023 doi "https://doi.org/10.1016/j.neuroscience.2003.11.009" @default.
• W1974790023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14751289" @default.
• W1974790023 hasPublicationYear "2004" @default.
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