FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974794370> ?p ?o ?g. }

• W1974794370 endingPage "826" @default.
• W1974794370 startingPage "817" @default.
• W1974794370 abstract "Cholangiocarcinoma in northeast Thailand is associated with liver fluke infection. Mechanisms of inactivation of the p15(INK4b), p16(INK4a), and p14(ARF) have been reported in many human cancers but have not hitherto been studied in liver fluke-related cholangiocarcinoma, particularly genetic and epigenetic effects on protein expression. We investigated loss of heterozygosity and microsatellite instability and performed fine mapping of the chromosomal region 9p21-pter in 94 microdissected cholangiocarcinoma samples using polymerase chain reaction based-microsatellite markers. Methylation and protein expression of p14(ARF), p15(INK4b), and p16(INK4a) was determined using methylation-specific polymerase chain reaction and immunohistochemistry, respectively. Genetic and epigenetic alterations, including loss of protein expression, were correlated with clinicopathological data. Fine mapping at 9p21-pter showed a distinctive region between D9S286 and D9S1752 of common loss. Methylation frequency was 40.2% for p14(ARF), 48.9% for p15(INK4b), and 28.3% for p16(INK4a). Loss of protein expression of p14(ARF), p15(INK4b), and p16(INK4a) was 30.9%, 58%, and 81.5%, respectively. Both p14(ARF) methylation and allelic loss at 9p21 were associated with loss of p14(ARF) expression. Poor prognosis was associated with loss of p16(INK4a) expression. In conclusion, mechanisms of inactivation of p14(ARF), p15(INK4b), and p16(INK4a) in liver fluke-related cholangiocarcinoma are preferentially different, by which epigenetic event being the main mechanism of p14(ARF), whereas p16(INK4a) and p15(INK4b) inactivation occurs through genetic and both genetic and epigenetic events, respectively." @default.
• W1974794370 created "2016-06-24" @default.
• W1974794370 creator A5013043572 @default.
• W1974794370 creator A5037244623 @default.
• W1974794370 creator A5050006382 @default.
• W1974794370 creator A5079039867 @default.
• W1974794370 creator A5081369303 @default.
• W1974794370 creator A5084089328 @default.
• W1974794370 creator A5087641489 @default.
• W1974794370 date "2009-06-01" @default.
• W1974794370 modified "2023-10-06" @default.
• W1974794370 title "Preferentially different mechanisms of inactivation of 9p21 gene cluster in liver fluke–related cholangiocarcinoma" @default.
• W1974794370 cites W1980636252 @default.
• W1974794370 cites W1982407801 @default.
• W1974794370 cites W1994465394 @default.
• W1974794370 cites W1997073961 @default.
• W1974794370 cites W2007902782 @default.
• W1974794370 cites W2023795717 @default.
• W1974794370 cites W2029080338 @default.
• W1974794370 cites W2032123392 @default.
• W1974794370 cites W2036332601 @default.
• W1974794370 cites W2039463309 @default.
• W1974794370 cites W2066848701 @default.
• W1974794370 cites W2077858999 @default.
• W1974794370 cites W2078720623 @default.
• W1974794370 cites W2081745064 @default.
• W1974794370 cites W2084891010 @default.
• W1974794370 cites W2087497617 @default.
• W1974794370 cites W2092884985 @default.
• W1974794370 cites W2099942653 @default.
• W1974794370 cites W2106561351 @default.
• W1974794370 cites W2113387363 @default.
• W1974794370 cites W2134158374 @default.
• W1974794370 cites W2136422121 @default.
• W1974794370 cites W2138406298 @default.
• W1974794370 cites W2146344535 @default.
• W1974794370 doi "https://doi.org/10.1016/j.humpath.2008.11.002" @default.
• W1974794370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19200577" @default.
• W1974794370 hasPublicationYear "2009" @default.
• W1974794370 type Work @default.
• W1974794370 sameAs 1974794370 @default.
• W1974794370 citedByCount "22" @default.
• W1974794370 countsByYear W19747943702012 @default.
• W1974794370 countsByYear W19747943702013 @default.
• W1974794370 countsByYear W19747943702014 @default.
• W1974794370 countsByYear W19747943702015 @default.
• W1974794370 countsByYear W19747943702016 @default.
• W1974794370 countsByYear W19747943702017 @default.
• W1974794370 countsByYear W19747943702018 @default.
• W1974794370 countsByYear W19747943702019 @default.
• W1974794370 countsByYear W19747943702020 @default.
• W1974794370 countsByYear W19747943702022 @default.
• W1974794370 crossrefType "journal-article" @default.
• W1974794370 hasAuthorship W1974794370A5013043572 @default.
• W1974794370 hasAuthorship W1974794370A5037244623 @default.
• W1974794370 hasAuthorship W1974794370A5050006382 @default.
• W1974794370 hasAuthorship W1974794370A5079039867 @default.
• W1974794370 hasAuthorship W1974794370A5081369303 @default.
• W1974794370 hasAuthorship W1974794370A5084089328 @default.
• W1974794370 hasAuthorship W1974794370A5087641489 @default.
• W1974794370 hasConcept C104317684 @default.
• W1974794370 hasConcept C143589142 @default.
• W1974794370 hasConcept C150194340 @default.
• W1974794370 hasConcept C153911025 @default.
• W1974794370 hasConcept C180754005 @default.
• W1974794370 hasConcept C190727270 @default.
• W1974794370 hasConcept C203014093 @default.
• W1974794370 hasConcept C204232928 @default.
• W1974794370 hasConcept C2779767149 @default.
• W1974794370 hasConcept C33288867 @default.
• W1974794370 hasConcept C41091548 @default.
• W1974794370 hasConcept C502942594 @default.
• W1974794370 hasConcept C54355233 @default.
• W1974794370 hasConcept C61320498 @default.
• W1974794370 hasConcept C86803240 @default.
• W1974794370 hasConceptScore W1974794370C104317684 @default.
• W1974794370 hasConceptScore W1974794370C143589142 @default.
• W1974794370 hasConceptScore W1974794370C150194340 @default.
• W1974794370 hasConceptScore W1974794370C153911025 @default.
• W1974794370 hasConceptScore W1974794370C180754005 @default.
• W1974794370 hasConceptScore W1974794370C190727270 @default.
• W1974794370 hasConceptScore W1974794370C203014093 @default.
• W1974794370 hasConceptScore W1974794370C204232928 @default.
• W1974794370 hasConceptScore W1974794370C2779767149 @default.
• W1974794370 hasConceptScore W1974794370C33288867 @default.
• W1974794370 hasConceptScore W1974794370C41091548 @default.
• W1974794370 hasConceptScore W1974794370C502942594 @default.
• W1974794370 hasConceptScore W1974794370C54355233 @default.
• W1974794370 hasConceptScore W1974794370C61320498 @default.
• W1974794370 hasConceptScore W1974794370C86803240 @default.
• W1974794370 hasIssue "6" @default.
• W1974794370 hasLocation W19747943701 @default.
• W1974794370 hasLocation W19747943702 @default.
• W1974794370 hasOpenAccess W1974794370 @default.
• W1974794370 hasPrimaryLocation W19747943701 @default.
• W1974794370 hasRelatedWork W1975299549 @default.
• W1974794370 hasRelatedWork W1988340380 @default.
• W1974794370 hasRelatedWork W2067182044 @default.

• next