FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974797420> ?p ?o ?g. }

• W1974797420 endingPage "23" @default.
• W1974797420 startingPage "15" @default.
• W1974797420 abstract "Schizophrenia is one of the major psychiatric disorders. It is a disorder of complex inheritance, involving both heritable and environmental factors. DNA methylation is an inheritable epigenetic modification that stably alters gene expression. We reasoned that genetic modifications that are a result of environmental stimuli could also make a contribution. We have performed 26 high-resolution genome-wide methylation array analyses to determine the methylation status of 27,627 CpG islands and compared the data between patients and healthy controls. Methylation profiles of DNAs were analyzed in six pools: 220 schizophrenia patients; 220 age-matched healthy controls; 110 female schizophrenia patients; 110 age-matched healthy females; 110 male schizophrenia patients; 110 age-matched healthy males. We also investigated the methylation status of 20 individual patient DNA samples (eight females and 12 males. We found significant differences in the methylation profile between schizophrenia and control DNA pools. We found new candidate genes that principally participate in apoptosis, synaptic transmission and nervous system development (GABRA2, LIN7B, CASP3). Methylation profiles differed between the genders. In females, the most important genes participate in apoptosis and synaptic transmission (XIAP, GABRD, OXT, KRT7), whereas in the males, the implicated genes in the molecular pathology of the disease were DHX37, MAP2K2, FNDC4 and GIPC1. Data from the individual methylation analyses confirmed, the gender-specific pools results. Our data revealed major differences in methylation profiles between schizophrenia patients and controls and between male and female patients. The dysregulated activity of the candidate genes could play a role in schizophrenia pathogenesis." @default.
• W1974797420 created "2016-06-24" @default.
• W1974797420 creator A5006825903 @default.
• W1974797420 creator A5006838317 @default.
• W1974797420 creator A5011418267 @default.
• W1974797420 creator A5025679852 @default.
• W1974797420 creator A5032178299 @default.
• W1974797420 creator A5066019459 @default.
• W1974797420 date "2014-12-01" @default.
• W1974797420 modified "2023-09-25" @default.
• W1974797420 title "Genome-Wide Methylation Profiling of Schizophrenia" @default.
• W1974797420 cites W1915010695 @default.
• W1974797420 cites W1963673462 @default.
• W1974797420 cites W1976896971 @default.
• W1974797420 cites W1979674827 @default.
• W1974797420 cites W1981990731 @default.
• W1974797420 cites W1984977154 @default.
• W1974797420 cites W1989378157 @default.
• W1974797420 cites W1989663044 @default.
• W1974797420 cites W1993421515 @default.
• W1974797420 cites W1999137631 @default.
• W1974797420 cites W1999478182 @default.
• W1974797420 cites W2020478383 @default.
• W1974797420 cites W2020986481 @default.
• W1974797420 cites W2036298036 @default.
• W1974797420 cites W203692480 @default.
• W1974797420 cites W2037256374 @default.
• W1974797420 cites W2039597975 @default.
• W1974797420 cites W2047626399 @default.
• W1974797420 cites W2048387161 @default.
• W1974797420 cites W2066656867 @default.
• W1974797420 cites W2067462101 @default.
• W1974797420 cites W2080527859 @default.
• W1974797420 cites W2084118479 @default.
• W1974797420 cites W2087609682 @default.
• W1974797420 cites W2088846224 @default.
• W1974797420 cites W2098597355 @default.
• W1974797420 cites W2101214870 @default.
• W1974797420 cites W2101259235 @default.
• W1974797420 cites W2108033168 @default.
• W1974797420 cites W2114327599 @default.
• W1974797420 cites W2117787632 @default.
• W1974797420 cites W2121281425 @default.
• W1974797420 cites W2121634929 @default.
• W1974797420 cites W2122230573 @default.
• W1974797420 cites W2123032740 @default.
• W1974797420 cites W2130189740 @default.
• W1974797420 cites W2134520666 @default.
• W1974797420 cites W2146804942 @default.
• W1974797420 cites W2151687527 @default.
• W1974797420 cites W2152656267 @default.
• W1974797420 cites W2153914575 @default.
• W1974797420 cites W2157836366 @default.
• W1974797420 cites W2168693035 @default.
• W1974797420 cites W2169773980 @default.
• W1974797420 cites W4211174138 @default.
• W1974797420 cites W86878820 @default.
• W1974797420 doi "https://doi.org/10.2478/bjmg-2014-0070" @default.
• W1974797420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4413438" @default.
• W1974797420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25937794" @default.
• W1974797420 hasPublicationYear "2014" @default.
• W1974797420 type Work @default.
• W1974797420 sameAs 1974797420 @default.
• W1974797420 citedByCount "15" @default.
• W1974797420 countsByYear W19747974202016 @default.
• W1974797420 countsByYear W19747974202018 @default.
• W1974797420 countsByYear W19747974202019 @default.
• W1974797420 countsByYear W19747974202020 @default.
• W1974797420 countsByYear W19747974202021 @default.
• W1974797420 countsByYear W19747974202022 @default.
• W1974797420 countsByYear W19747974202023 @default.
• W1974797420 crossrefType "journal-article" @default.
• W1974797420 hasAuthorship W1974797420A5006825903 @default.
• W1974797420 hasAuthorship W1974797420A5006838317 @default.
• W1974797420 hasAuthorship W1974797420A5011418267 @default.
• W1974797420 hasAuthorship W1974797420A5025679852 @default.
• W1974797420 hasAuthorship W1974797420A5032178299 @default.
• W1974797420 hasAuthorship W1974797420A5066019459 @default.
• W1974797420 hasBestOaLocation W19747974201 @default.
• W1974797420 hasConcept C104317684 @default.
• W1974797420 hasConcept C118552586 @default.
• W1974797420 hasConcept C140173407 @default.
• W1974797420 hasConcept C150194340 @default.
• W1974797420 hasConcept C190727270 @default.
• W1974797420 hasConcept C2776412080 @default.
• W1974797420 hasConcept C33288867 @default.
• W1974797420 hasConcept C41091548 @default.
• W1974797420 hasConcept C54355233 @default.
• W1974797420 hasConcept C69991583 @default.
• W1974797420 hasConcept C71924100 @default.
• W1974797420 hasConcept C86803240 @default.
• W1974797420 hasConceptScore W1974797420C104317684 @default.
• W1974797420 hasConceptScore W1974797420C118552586 @default.
• W1974797420 hasConceptScore W1974797420C140173407 @default.
• W1974797420 hasConceptScore W1974797420C150194340 @default.
• W1974797420 hasConceptScore W1974797420C190727270 @default.
• W1974797420 hasConceptScore W1974797420C2776412080 @default.
• W1974797420 hasConceptScore W1974797420C33288867 @default.

• next