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• W1974800178 endingPage "37" @default.
• W1974800178 startingPage "25" @default.
• W1974800178 abstract "Excessive and sustained exposure to glutamate leads to injurious elevations of cytosolic calcium ([Ca(2+)]i), generation of reactive oxygen and nitrogen species (ROS, RNS), mitochondrial failure, mobilization of intracellular zinc ([Zn(2+)]i), and, ultimately, neuronal death. The relative contribution and temporal dynamics of the activation of these processes to promote the full development of excitotoxicity are still not completely understood. In this study, we exploited the unique features of nNOS positive neurons [nNOS (+)], a striatal subpopulation that is constitutively spared from NMDAR-dependent insults, and dissected NMDAR-driven [Ca(2+)]i, [Zn(2+)]i, ROS, and mitochondrial changes occurring in these neurons and the overall population of nNOS (-) striatal neurons. Comparing the two populations and employing pharmacological, biochemical, and single-cell imaging techniques, we show that [Zn(2+)]i mobilization acts as a critical intermediate in the cascade that links NMDAR-mediated ROS overproduction, mitochondrial failure, and [Ca(2+)]i deregulation to the production of neuronal damage. Results of this study may also provide the rationale for aiming at therapeutic agents that favor Zn(2+) homeostasis for the treatment of acute or chronic neurological conditions associated with excitotoxicity." @default.
• W1974800178 created "2016-06-24" @default.
• W1974800178 creator A5031328280 @default.
• W1974800178 creator A5058319971 @default.
• W1974800178 date "2015-09-01" @default.
• W1974800178 modified "2023-10-05" @default.
• W1974800178 title "Intracellular zinc is a critical intermediate in the excitotoxic cascade" @default.
• W1974800178 cites W1484597533 @default.
• W1974800178 cites W1515063177 @default.
• W1974800178 cites W1553877517 @default.
• W1974800178 cites W1563847798 @default.
• W1974800178 cites W1564601025 @default.
• W1974800178 cites W1594829953 @default.
• W1974800178 cites W1596817582 @default.
• W1974800178 cites W1935060748 @default.
• W1974800178 cites W1958675123 @default.
• W1974800178 cites W1967117930 @default.
• W1974800178 cites W1969709153 @default.
• W1974800178 cites W1972771185 @default.
• W1974800178 cites W1974896979 @default.
• W1974800178 cites W1980311878 @default.
• W1974800178 cites W1982838468 @default.
• W1974800178 cites W1993385893 @default.
• W1974800178 cites W1996156357 @default.
• W1974800178 cites W1996568613 @default.
• W1974800178 cites W1996818725 @default.
• W1974800178 cites W2002091021 @default.
• W1974800178 cites W2005571058 @default.
• W1974800178 cites W2008380097 @default.
• W1974800178 cites W2011629756 @default.
• W1974800178 cites W2013063789 @default.
• W1974800178 cites W2015094152 @default.
• W1974800178 cites W2015807826 @default.
• W1974800178 cites W2016619600 @default.
• W1974800178 cites W2017761002 @default.
• W1974800178 cites W2018110972 @default.
• W1974800178 cites W2020124596 @default.
• W1974800178 cites W2020178087 @default.
• W1974800178 cites W2020265449 @default.
• W1974800178 cites W2024380057 @default.
• W1974800178 cites W2027064502 @default.
• W1974800178 cites W2029107363 @default.
• W1974800178 cites W2032455525 @default.
• W1974800178 cites W2033673006 @default.
• W1974800178 cites W2033678540 @default.
• W1974800178 cites W2035464530 @default.
• W1974800178 cites W2035752728 @default.
• W1974800178 cites W2036297514 @default.
• W1974800178 cites W2036839645 @default.
• W1974800178 cites W2042550512 @default.
• W1974800178 cites W2044185633 @default.
• W1974800178 cites W2049748263 @default.
• W1974800178 cites W2051485869 @default.
• W1974800178 cites W2052991500 @default.
• W1974800178 cites W2054566340 @default.
• W1974800178 cites W2057520074 @default.
• W1974800178 cites W2058307574 @default.
• W1974800178 cites W2059964363 @default.
• W1974800178 cites W2060893933 @default.
• W1974800178 cites W2063262838 @default.
• W1974800178 cites W2063336891 @default.
• W1974800178 cites W2064750728 @default.
• W1974800178 cites W2070085673 @default.
• W1974800178 cites W2075076460 @default.
• W1974800178 cites W2075876062 @default.
• W1974800178 cites W2076403022 @default.
• W1974800178 cites W2076747818 @default.
• W1974800178 cites W2082470605 @default.
• W1974800178 cites W2082651452 @default.
• W1974800178 cites W2082879602 @default.
• W1974800178 cites W2085273994 @default.
• W1974800178 cites W2087140031 @default.
• W1974800178 cites W2089796673 @default.
• W1974800178 cites W2090734822 @default.
• W1974800178 cites W2094752641 @default.
• W1974800178 cites W2095218706 @default.
• W1974800178 cites W2097293665 @default.
• W1974800178 cites W2098227836 @default.
• W1974800178 cites W2103105379 @default.
• W1974800178 cites W2105202319 @default.
• W1974800178 cites W2118546680 @default.
• W1974800178 cites W2121642311 @default.
• W1974800178 cites W2127394252 @default.
• W1974800178 cites W2131437696 @default.
• W1974800178 cites W2133569747 @default.
• W1974800178 cites W2135314348 @default.
• W1974800178 cites W2138149556 @default.
• W1974800178 cites W2138298723 @default.
• W1974800178 cites W2139625864 @default.
• W1974800178 cites W2148999943 @default.
• W1974800178 cites W2149497936 @default.
• W1974800178 cites W2155747798 @default.
• W1974800178 cites W2167279371 @default.
• W1974800178 cites W2277044615 @default.
• W1974800178 cites W2576842289 @default.
• W1974800178 cites W4249424055 @default.
• W1974800178 cites W2076211518 @default.
• W1974800178 doi "https://doi.org/10.1016/j.nbd.2015.04.010" @default.

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